sperm antibody

sperm antibody

a glycoprotein that specifically recognizes the head or tail of a spermatozoon. The antibodies are found often in vasectomized males and infrequently in infertile males.

anti-sperm antibody

Any of a group of antibodies produced against four distinct components of the sperm. While ASAs are linked to infertility, their presence is not associated with a particular disease; ASAs may be found in the circulation, either free or as immune complexes, in seminal fluid and/or attached to the sperm surface.
 
Ref range/normal
IgA, IgG, IgM < 15% binding.
 
Low titres (< 1:8 of ASAs) are present in 90% of prepubertal boys and are of no significance; up to 50% of infertile women have anti-sperm antibody titres of ≥ 1:16, most commonly as IgG or IgA anti-sperm (tail-immobilising) antibodies, while male homosexuals tend to develop IgM anti-sperm (head-agglutinating) antibodies.
 
Specimen
Serum, semen IgE.
 
Method
ELISA.
References in periodicals archive ?
Comparison of the sperm Mar test with currently accepted procedures for detection of human sperm antibody.
Sperm antibody testing should be recommended to the physician when agglutination is present.
These include tray slide sperm agglutination, mixed agglutination reaction, sperm immobilization, sperm cytotoxicity, ELISA, indirect immunofluorescence, radiolabeled antiglobulin, immunobead binding, and flow cytometric sperm antibody.