sperm antibody

sperm antibody

a glycoprotein that specifically recognizes the head or tail of a spermatozoon. The antibodies are found often in vasectomized males and infrequently in infertile males.

anti-sperm antibody

Any of a group of antibodies produced against four distinct components of the sperm. While ASAs are linked to infertility, their presence is not associated with a particular disease; ASAs may be found in the circulation, either free or as immune complexes, in seminal fluid and/or attached to the sperm surface.
 
Ref range/normal
IgA, IgG, IgM < 15% binding.
 
Low titres (< 1:8 of ASAs) are present in 90% of prepubertal boys and are of no significance; up to 50% of infertile women have anti-sperm antibody titres of ≥ 1:16, most commonly as IgG or IgA anti-sperm (tail-immobilising) antibodies, while male homosexuals tend to develop IgM anti-sperm (head-agglutinating) antibodies.
 
Specimen
Serum, semen IgE.
 
Method
ELISA.
References in periodicals archive ?
Special applications of intracytoplasmic sperm injection: the influence of sperm count, motility, morphology, source and sperm antibody on the outcome of ICSI.
The DRG Sperm Antibody ELISA is a solid-phase sandwich enzyme-immunoassay for the determination of anti-spermatozoa antibodies in human serum.
Sperm antibody testing should be recommended to the physician when agglutination is present.