sperm agglutination test


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sperm agglutination test

(for male factor infertility) any of various tests for presence of antisperm antibodies as a cause of infertility, based on the ability of large multivalent isotypes, such as IgM or secretory IgA, to cross-link and agglutinate spermatozoa that have such antibodies. Serum or seminal plasma is mixed with a known concentration of sperm; immunoglobulins in the mixture then begin agglutinating the sperm. After a given period of time at 37° C, the amount of agglutination is assessed.