specific pathogen free


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specific pathogen free

a term applied to animals reared for experimentation or to commence new herds or flocks of disease-free animals; abbreviated SPF. Animals usually obtained as for axenic animals but are then placed into a nonsterile environment in which they become infected with a range of microorganisms, many colonizing as so-called normal flora. Certain defined specific pathogenic microorganisms are not present in the environment so that SPF animals can be stated to be free of infection or previous infection with the specified microorganism. See also gnotobiotic animal.
References in periodicals archive ?
Pathogenicity of Salmonella enteritidis phage types 4, 8 and 23 in specific pathogen free chicks.
Supply of equipment for washing, sterilizing and reconditioning materials, production, and maintenance Phenotyping barrierato and controlled environment and Specific Pathogen Free Oportunistic (opf) of mouse colonies Genetically Engineered and Mutant Mice (GEMM) and furniture from laboratory attached to the analysis of phenotype.
University of Connecticut, Storrs, Connecticut, USA; and ([dagger])Charles River Specific Pathogen Free Avian Supplies, Storrs, Connecticut, USA
To determine the pathogenicity of the isolate, 8 6-week-old specific pathogen free chickens were inoculated intravenously with the virus.
Rather than using TSV-infected shrimp originated from shrimp farms as a source, TSV infection was induced under laboratory conditions by injecting specific pathogen free (SPF) shrimp (10) Litopenaeus vannamei with purified TSV reference isolate Hawaii-94 (11).
b) BGMK, Buffalo green monkey kidney; FrhK-4, monkey Rhesus female kidney embryonic, MA-104, monkey African green kidney; TSV; Taura syndrome virus; SPF, specific pathogen free.
The animals should be Specific Pathogen Free and should be bred and maintained in accordance with Home Office and EU guidelines.