and spasmolytic activities of lavandula Stoechas are mediated through muscarinic receptor stimulation and calcium channel blockade.
Ginger extract contains a cholinergic and spasmogenic
component, which provides a mechanistic insight for the prokinetic action of ginger.
Factor C3f is a spasmogenic
fragment released from C3b by factors I and H: the heptadeca-peptide C3f was synthesized and characterized.
The antagonistic effect of urantide is highly selective, only acting against the vasoconstrictive effect of U-II by ignoring the responses produced by different spasmogenic
compounds, such as noradrenaline and ET-1 [26, 27].
Data show that Cydonia oblonga possesses spasmogenic
effect mediated through cholinergic pathway, while Ca++ antagonist like mechanism is found responsible for its spasmolytic activity, thus provides justification for the medicinal use of the plant in gut and airways disorders.
, spasmolytic and antihypertensive activity of Forsskalea tenacissima L.
For example: spasmogenic
effect of crude saponin fraction isolated form Panax ginseng was completely inhibited by atropine (Takagi et al.
Its hydroalcoholic extract in rabbit jejunum showed spasmolytic and spasmogenic
effects hence its use in abdominal cramps and constipation.
It is used as spasmogenic
, oxytocic, uterotonic, anti-bacterial, anti-implantation, anti-tumour, anti-progestational, antiestrogenic activity against menorrhagia and anti-cancer.
Histamine and methacholine have a direct spasmogenic
effect on airway smooth muscle cells.
Current research suggests that spasmogenic
substances such as serotonin, prostaglandins, catecholamines, and histamine are released as the hemorrhagic clot dissolves.
It has also been used in reptile insect, depurative, sedative, stomatic, hepatoprotective, leucoderma, blood purifier, diarrhoea, alkality, rectal prolapse, coronary heart diseases,6 anticholesterol, antiviral, lymphatic glandular system disease, chronic catarrh, carbubuncles, antidiabetic, dysmenorrhoea impetigo, aphrodisiac, urinary infection, calculus7,8 as well as vomiting,9 antioxidant,10 spasmolytic and spasmogenic