sotalol


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sotalol

 [so´tah-lol]
a non-cardioselective beta-adrenergic blocking agent, used as the hydrochloride salt in treatment of life-threatening ventricular arrhythmias.

sotalol

(sō′tə-lôl′, -lōl′)
n.
A beta-blocker drug, C12H20N2O3S, used in its hydrochloride form to treat certain cardiac arrhythmias.

Betapace AF

A racemic mixture of d- and l-sotalol, with beta-blocking (class II) and cardiac action potential duration prolongation (class-III antiarrhythmic properties).

Adverse effects
Fatigue, bradycardia, proarrhythmia, dyspnea, diarrhoea, nausea, vomiting, QT-interval prolongation, nonspecific increase in liver enzymes.

sotalol

Betapace®, Sotacor® Cardiology A class II beta blocker that ↑ myocardial action potential duration, ↑ cardiac refractory period, lengthens QT interval; sotalol is used for conduction block, A Fib, torsade de pointes, angina, HTN, suppress PVCs, ventricular tachyarrhythmias Adverse effects Proarrhythmia due to ↑ β blockade; it may aggravate pre-existing arrhythmias–eg, sinus bradycardia, provoke new arrhythmias–eg, torsade de points–±2.5%, exacerbate CHF, hypotension, bronchospasm, fatigue, dizziness, dyspnea, headache. See β-blocker, SWORD.

sotalol

A long-acting beta-blocker drug used to treat irregularity of the heart action. Brand names are Beta-Cardone and Sotacor.
References in periodicals archive ?
Efficacy and safety of sotalol in digitalized patients with chronic atrial fibrillation: the Sotalol Study Group.
In the rhythm-control group, amiodarone and sotalol were prescribed most frequently.
A daily dosage of 320 mg of sotalol was given to 383 patients, a daily dosage of 480 mg of quinidine plus 240 mg of verapamil was given to 377 patients, and 88 patients were randomized to placebo.
Coadministration of flecainide acetate and sotalol during pregnancy: lack of teratogenic effects, passage across the placenta, and excretion in human breast milk.
In the last 12 months, Epic Pharma has launched azithromycin powder for oral solution, sotalol AF tablets as well as the first soft-gel product, dutasteride capsules 0.5 mg.
This is Beximco's fourth product for the US market following the successful launches of Carvedilol, Sotalol and Methocarbamol.
Historically, maintaining sinus rhythm has meant prescribing antiarrhythmic medications, such as amiodarone (Cordarone[R], Pacerone[R]), dofetilide (Tikosyn[R]), dronedarone (Multaq[R]), flecainide (Tambocor[R]), propafenone (Rhythmol[R]), and Sotalol (Betapace[R]).
> Rhythm control medications, including flecainide (Tambocor), propafenone (Rythmol), Sotalol (Betapace), amiodarone (Cordarone, Pacerone), and dronedarone (Multaq)
Multiple agents, including [beta]-blockers, nondihydropyridine calcium channel blockers, digoxin, and certain antiarrhythmic drugs, including amiodarone and sotalol, have been evaluated for efficacy in attaining rate control [1].
The [I.sub.to] blocker 4-AP, [I.sub.Kr] blockers E-4031 and sotalol, and [I.sub.Ks] blocker chromalol 293B prolonged APD50 and APD90.
According to the results from a prospective, randomized study on paroxysmal atrial fibrillation (PAF) due to hyperthyroidism, sinus rhythm was observed in 91.2% of patients with Wenxin Keli and 89.9% of patients with sotalol after three months [12].