Sorbitol pathway | definition of sorbitol pathway by Medical dictionary
a pathway responsible for d-fructose formation from sorbitol; increases in activity as the glucose concentration rises in diabetes.
References in periodicals archive
18) In the sorbitol pathway glucose undergoes reduction by NADPH to sorbitol followed by oxidation of sorbitol to fructose in the presence of [NAD.
Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism.
The consistently elevated blood glucose flows to sorbitol pathway
causes increased utilisation of Nicotinamide Adenine Dinucleotide Phosphate-Oxidase (NADPH), which subsequently increases trios-phosphate concentration and thus generates excessive amounts of MG.