sorbitol pathway

sor·bi·tol path·way

a pathway responsible for d-fructose formation from sorbitol; increases in activity as the glucose concentration rises in diabetes.
Synonym(s): polyol pathway
References in periodicals archive ?
Gabbay, "The sorbitol pathway and the complications of diabetes," The New England Journal of Medicine, vol.
Obrosova, "Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications," Antioxidants & Redox Signaling, vol.
(18) In the sorbitol pathway glucose undergoes reduction by NADPH to sorbitol followed by oxidation of sorbitol to fructose in the presence of [NAD.sup.+] and sorbitol dehydrogenase.
Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism.
Williamson, "Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism: implications for diabetic retinopathy," Investigative Ophthalmology and Visual Science, vol.
Previous studies from our group have shown that obesity [18, 19] as well as prediabetes [20] is associated with increased susceptibility to cataract formation due to the activation of sorbitol pathway in experimental animals.
Cheng, "The effect of oxidation on sorbitol pathway kinetics," Diabetes, vol.