Gabbay, "The sorbitol pathway
and the complications of diabetes," The New England Journal of Medicine, vol.
Obrosova, "Increased sorbitol pathway
activity generates oxidative stress in tissue sites for diabetic complications," Antioxidants & Redox Signaling, vol.
(18) In the sorbitol pathway glucose undergoes reduction by NADPH to sorbitol followed by oxidation of sorbitol to fructose in the presence of [NAD.sup.+] and sorbitol dehydrogenase.
Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism.
Williamson, "Elevated glucose levels increase retinal glycolysis and sorbitol pathway
metabolism: implications for diabetic retinopathy," Investigative Ophthalmology and Visual Science, vol.
Previous studies from our group have shown that obesity [18, 19] as well as prediabetes  is associated with increased susceptibility to cataract formation due to the activation of sorbitol pathway
in experimental animals.
Cheng, "The effect of oxidation on sorbitol pathway
kinetics," Diabetes, vol.