sorbitol pathway

sor·bi·tol path·way

a pathway responsible for d-fructose formation from sorbitol; increases in activity as the glucose concentration rises in diabetes.
Synonym(s): polyol pathway
References in periodicals archive ?
18) In the sorbitol pathway glucose undergoes reduction by NADPH to sorbitol followed by oxidation of sorbitol to fructose in the presence of [NAD.
Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism.
The consistently elevated blood glucose flows to sorbitol pathway causes increased utilisation of Nicotinamide Adenine Dinucleotide Phosphate-Oxidase (NADPH), which subsequently increases trios-phosphate concentration and thus generates excessive amounts of MG.