Patient in case 5 was treated in 1 h 15 min, using 31 sonications with an energy range of 1051-446 J using small, large, and elongated spots.
We included patients with less than 6 clinically significant submucosal, intramural, and/or subserosal fibroids greater than 3 cm (since the smaller sonication spot with our MRgFUS system is 2.5 cm; see asterisks in Figure 1(a)) and smaller than 10 cm (to avoid longer treatment time; Figure 1(b)).
As a safety measure, a "stop sonication button" is placed in patient's hand and one more button is available on the workstation that the operating physician uses during treatment.
In our practice, the average treatment time (from the first low-energy sonication to the last therapeutic one) was about 150 minutes.
Sonication of VX2 tumours resulted in accurate and spatially homogenous temperature control in the target region.
The authors used immunoelectron microscopy to identify tight junctional proteins such as occludin, claudin-1, claudin-5, and submembranous ZO-1 after sonication. They found substantial redistribution and loss of occludin, claudin-5 and ZO-1.
Prior to each sonication, AP-1 Lipo-Dox or unconjugated LipoDox were administered intravenously, and the concentration in the brain was quantified.
Hynynen, "Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate," Ultrasound in Medicine and Biology, vol.