GH-1 is expressed in somatotroph
cells of pituitary whereas other paralogues are all placentally expressed.
The lateral part of the pars distalis: pars distalis (PaD), acidophilic cell (AC), basophilic cell (BC), chromophobe cell (CC), sinusoid (Sin), somatotroph
cell (SC), thyrotroph cell (TC), gonadotroph cell (GC), corticotroph cell (ACTHC).
Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph
proliferation and normal somatic growth.
Impact of gsp mutations in somatotroph
pituitary adenomas on growth hormone response to somatostatin analogs: a meta-analysis.
This possibility is supported by the presence of GH immunoreactivity in the brain prior to the ontogeny of the pituitary gland and somatotroph
differentiation, as has been demonstrated in the human and chicken brain (20,21).
Eighteen of 20 patients carried PROP1 mutations had gonadotroph and somatotroph
deficiency at postpubertal age, while two patients had corticotroph, thyrotroph, and somatotroph
deficiency at pubertal age.
Lugli et al., "Factors predicting pasireotide responsiveness in somatotroph
pituitary adenomas resistant to first-generation somatostatin analogues: an immunohistochemical study," European Journal of Endocrinology, vol.
It increases growth hormone secretion per cell by depolarizing somatotroph
membrane and by stimulating receptors present on immune cells20.
Raams et al., "A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph
axis," Nature, vol.
Stress-induced HPA axis activation and GH-induced somatotroph
adenoma growth are mediated via the STAT3 pathway .
adenomas patients were significantly likely to present with abnormal glucose metabolism, independent of GH/IGF-1 levels or tumor invasiveness .
Growth hormone (GH) is produced by somatotroph
cells of the anterior pituitary gland.