GH-1 is expressed in
somatotroph cells of pituitary whereas other paralogues are all placentally expressed.
The lateral part of the pars distalis: pars distalis (PaD), acidophilic cell (AC), basophilic cell (BC), chromophobe cell (CC), sinusoid (Sin),
somatotroph cell (SC), thyrotroph cell (TC), gonadotroph cell (GC), corticotroph cell (ACTHC).
Neuronal M3 muscarinic acetylcholine receptors are essential for
somatotroph proliferation and normal somatic growth.
Impact of gsp mutations in
somatotroph pituitary adenomas on growth hormone response to somatostatin analogs: a meta-analysis.
This possibility is supported by the presence of GH immunoreactivity in the brain prior to the ontogeny of the pituitary gland and
somatotroph differentiation, as has been demonstrated in the human and chicken brain (20,21).
Eighteen of 20 patients carried PROP1 mutations had gonadotroph and
somatotroph deficiency at postpubertal age, while two patients had corticotroph, thyrotroph, and
somatotroph deficiency at pubertal age.
Lugli et al., "Factors predicting pasireotide responsiveness in
somatotroph pituitary adenomas resistant to first-generation somatostatin analogues: an immunohistochemical study," European Journal of Endocrinology, vol.
It increases growth hormone secretion per cell by depolarizing
somatotroph membrane and by stimulating receptors present on immune cells20.
Raams et al., "A new progeroid syndrome reveals that genotoxic stress suppresses the
somatotroph axis," Nature, vol.
Stress-induced HPA axis activation and GH-induced
somatotroph adenoma growth are mediated via the STAT3 pathway [107].
Pure
somatotroph adenomas patients were significantly likely to present with abnormal glucose metabolism, independent of GH/IGF-1 levels or tumor invasiveness [21].
Growth hormone (GH) is produced by
somatotroph cells of the anterior pituitary gland.
