The expression of E-cadherin in
somatotroph pituitary adenomas is related to tumor size, invasiveness, and somatostatin analog response.
It increases growth hormone secretion per cell by depolarizing
somatotroph membrane and by stimulating receptors present on immune cells20.
Growth hormone (GH) is produced by
somatotroph cells of the anterior pituitary gland.
Pure
somatotroph adenomas patients were significantly likely to present with abnormal glucose metabolism, independent of GH/IGF-1 levels or tumor invasiveness [21].
Granulation pattern, but not GSP or GHR mutation, is associated with clinical characteristics in somatostatin-naive patients with
somatotroph adenomas.
The endocrine responses to ghrelin are not modified by its co-administration with HEX which indicates the reproducibility of
somatotroph responsiveness to ghrelin.
In this regard it is noteworthy that it has been proposed that an interaction occurs between the
somatotroph and gonadotroph hormonal axes, represented by 17-MT and GH (Holloway & Leatherland 1998, Holloway et al.
Patients with dilated cardiomyopathy show reduction of the
somatotroph responsiveness to GHRH both alone and combined with arginine.
In this paper, we reported a male patient who had acromegaly, probably secondary to a pituitary
somatotroph adenoma but now has hypopituitarism with secondary adrenal insufficiency and hypopituitarism.
Proliferation of lactosomatotroph GH3 and
somatotroph MtT/S rat pituitary cells as well as of corticotroph AtT20 mouse pituitary cells was inhibited by curcumin in monolayer cell culture and in colony formation assay in soft agar.
Silent mixed corticotroph and
somatotroph macroadenomas presenting with pituitary apoplexy.
Growth hormone (GH) releasing peptide stimulation of GH release from human
somatotroph adenoma cells: interaction with GH-releasing hormone, thyrotropin-releasing hormone, and octreotide.
