somatostatins


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somatostatins

Tetradecapeptides widely distributed in the body, that inhibits the secretion of many HORMONES and NEUROTRANSMITTERS. Somatostatins are secreted in the hypothalamus, elsewhere in the brain, the gastrointestinal tract, pancreas, retina, spinal cord and various endocrine glands. They have been suggested as antidotes to growth hormone in conditions such as ACROMEGALY but have a very short duration of action and their use results in rebound over-secretion. The drug octreotide (Sandostatin) is a somatostatin analogue.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The choice to target somatostatin receptors is based on the analysis of expression levels of SSTRs in relatively small groups of human corticotroph pituitary adenomas ranging from 1 to 13 cases using RT-PCR [17-22] and the experience that had been gained with inhibitory substances in other endocrine tumors and diseases [21].
Somatostatin receptors can also be utilized as a target for peptide receptor radionuclide therapy (PRRT).
The methodology of this study allows a clear statement about the expression levels of all 5 somatostatin receptors in routine diagnostics with regard to differentiating real tumor cell expression from false-positive expression in vascular structures or other adjacent nonadenomatous tissue.
Endogenous hypothalamic somatostatins differentially regulate growth hormone secretion from goldfish pituitary somatotropes in vitro.
Somatostatin (SS) is a neuropeptide family which effects growth, development and metabolism.
Coilia nasus, Somatostatin, Molecular cloning, Growth hormone, Cortistatin, Embryonic development.
Somatostatin Receptor Expression and Functions in Normal Tissues
Somatostatin Receptor Signal Transduction, Homo- and Heterodimerization, and Trafficking
Radioactive Somatostatin Analogs for Imaging and Therapy
(1998) Changes in plasma somatostatin associated with seawater adaptation and stunting of coho salmon, Oncorhynchus kisutch.
(1997) Nutritional state affects somatostatin gene expression in rainbow trout.
Specialists in endocrinology, physiology, oncology, pathology, and nuclear medicine mainly from Europe survey analogues to the hormone somatostatin and their use in tumor diagnosis and therapy.