somatostatinoma syndrome

somatostatinoma syndrome

Oncology A paraneoplastic syndrome caused by ectopic somatostatin secretion Clinical Vomiting, hypochlorhydria, abdominal pain, diarrhea, malabsorption, weight loss, cholelithiasis, ↓ glucose control, causing 2º DM Lab ↑ somatostatin–an inhibitory hormone, evoking reactive ↓ insulin, ↓ glucagon, ↓ gastrin, steatorrhea, anemia
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43,44) These glandular carcinoids often contain psammoma bodies but do not produce the somatostatinoma syndrome as reported in patents with pancreatic endocrine D cell tumors.
Although they secrete somatostatin, somatostatinomas do not produce the somatostatinoma syndrome in MEN 1 patients.