SSTR2

(redirected from somatostatin receptor type 2)

SSTR2

A gene on chromosome 17q24 that encodes a G protein-coupled somatostatin receptor for somatostatin-14 and -28. It interacts with SHANK1 and is expressed in the brain and kidneys.
References in periodicals archive ?
The company's lead product candidate, CRN00808, is an oral selective nonpeptide somatostatin receptor type 2 biased agonist undergoing two Phase 2 clinical trials for the treatment of acromegaly, an orphan disease affecting more than 25,000 people in the United States.
Expression of somatostatin receptor type 2 and mammalian rapamycin target signaling activation patterns has also been reported.
Somatostatin receptor type 2 antagonism improves glucagon and corticosterone counterregulatory responses to hypoglycemia ins treptozotocin-induced diabetic rats.
Orlando et al., "Imaging of somatostatin receptors by indium-111-pentetreotide correlates with quantitative determination of somatostatin receptor type 2 gene expression in neuroblastoma tumors," Clinical Cancer Research, vol.
Bondioni et al., "Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2, " Endocrine-Related Cancer, vol.