Buyume hormonu ve somatomedin-C'nin B lenfositleri aktive ettigi ve somotomedin-C reseptorlerinin multiple myeloma hucrelerinde bulundugu daha onceden gosterilmistir.
Previous studies have shown that growth hormone and somatomedin-C activate B lymphocyte and somatomedin-C receptors are found in multiple myeloma cells.
Furthermore, we have demonstrated increased linear growth in Thalassemia-major patients when they were supplemented with daily Zn sulphate, in a controlled manner, indicating the fact that Zn was responsible from short stature in these patients  ILGF-1 (initially named as somatomedin-C
) levels were also measured in some of the thalassemia major patients and found to be low (4) It was an established fact that zinc plays an important role in the synthesis of ILGF-1 in liver [4,5].
Our group previously reported that zinc deficiency may affect the generation of somatomedin-C
which in turn named as Insulin growth factor-1 (IGF-1) Decreased IGF-1 levels were reported by us and others in beta thalassemia major patients .