somatomedin


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Related to somatomedin: Somatomedin C

somatomedin

 [so″mah-to-me´din]
any of a group of peptides found in the liver and in other tissues which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased synthesis of collagen and other proteins by cartilage. Somatomedins also have insulinlike biologic actions and increase RNA synthesis and promote DNA synthesis.

so·ma·to·me·din

(sō'mă-tō-mē'din),
One of several peptides; somatomedin peptide (MW about 4,000), also called insulinlike growth factor II, is synthesized in the liver and probably in the kidney; it is capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein (including chondromucoprotein), and the sulfation of mucopolysaccharides; secretion and biologic activity of somatomedin is known to depend on somatotropin.
See also: insulinlike growth factor.
[somato, tropin + mediator + -in]

somatomedin

(sō-măt′ə-mēd′n, sō′mə-tə-)

somatomedin

Any of a group of hormones that mediate the effects of growth hormone (formally, somatopropin):
(1) Insulin-like growth factor-I (somatomedin C);
(2) Insulin-like growth factor-II (somatomedin A);
(3) Vitronectin (somatomedin B).

so·ma·to·me·din

(sō'mă-tō-mē'din)
A peptide synthesized in the liver, and probably also in the kidney, capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein, and the sulfation of mucopolysaccharides; secretion or biologic activity of somatomedin is known to depend on somatotropin.
[somato, tropin + mediator + -in]

so·ma·to·me·din

(sō'mă-tō-mē'din)
One of several peptides; also called insulinlike growth factor II, is synthesized in the liver and probably kidney.
[somato, tropin + mediator + -in]
References in periodicals archive ?
Increased expression in Escherichia coli of a synthetic gene encoding human somatomedin C after gene duplication and fusion.
At the 6-week appointment, all pituitary hormones such as serum cortisol, prolactin, thyroid stimulating hormone, triiodothyronine (T3), thyroxine (T4), follicle stimulating hormone, luteinize hormone, somatomedin C (IGF-1), and testosterone will be checked by the endocrinologist.
It doesn't show any direct action on bones, but acts through a substance called somatomedin. GH stimulates liver to secrete somatomedin.
Soomro et al showed 69% of cirrhotic patients have hypozincemia.19In thalassemic patients with liver injury the release of somatomedin C is low.
Growth hormone secretion and plasma somatomedin C in hypothyroidism.
Somatomedin C levels in growth imparied children and adolescents with chronic inflammatory bowel disease: a prospective study.
Somatomedin C, buyume hormonu, tiroid fonksiyon testleri, ostradiol, prolaktin, kortizol ve antidiuretik hormon normal sinirlardaydi.
Patofizyolojide Hipotalamus-hipofiz adrenal aks (HPA) duzensizligi, Substans P, kortizol, serotonin, norepinefrin ve Somatomedin C duzeyi degisiklikleri gibi noroendokrin islev bozukluklari uzerinde durulmaktadir (9).
A number of investigations were performed: she was found to have an advanced bone age on X-ray; somatomedin C and TSH levels were normal; and chromosome studies revealed a normal female karyotype--46XX.