somatic mutation


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Related to somatic mutation: Somatic hypermutation

mutation

 [mu-ta´shun]
1. a permanent transmissible change in the genetic material.
2. an individual exhibiting such a change.
point mutation a mutation resulting from a change in a single base pair in the DNA molecule.
somatic mutation a genetic mutation occurring in a somatic cell, providing the basis for mosaicism.
suppressor mutation the correction of the effect of a mutation at one locus by a mutation at another locus.

so·mat·ic mu·ta·tion

a mutation occurring in the general body cells (as opposed to the germ cells) and hence not transmitted to progeny.

Acquired Mutation

Genetics A post-meiotic alteration in a DNA sequence, which can be passed to the mutated cell’s progeny and linked to the development of cancer.
Molecular biology A non-heritable genetic change in a somatic cell; a somatic mutation.

so·mat·ic mu·ta·tion

(sō-mat'ik myū-tā'shŭn)
A change that occurs in the general body cells (as opposed to the germ cells) and hence not transmitted to progeny.

somatic mutation

A mutation affecting SOMATIC cells that can affect only those cells and their offspring, so cannot be passed on to future generations. Such a mutation dies with the death of the individual.

somatic mutation

see MUTATION.
References in periodicals archive ?
analyzed the state of neurofibromas in 37 patients with neurofibromatosis type 1 and found somatic mutations in 7 patients with cutaneous neurofibromas (37%) and in 9 patients with plexiform neurofibroma (50%).
Targeted panels and whole-genome NGS assay detect somatic mutations in up to 90% of MDS patients (63-65).
Considering the potential evolutionary significance of somatic mutations in clonal organisms, we aim to assess the pervasiveness of intraorganismal genetic variation in these species and to determine whether the occurrence of somatic mutations is related to clonal size and an individual's previous exposure to abiotic stressors via a depth gradient.
Concordant acute myeloblastic leukemia in monozygotic twins with germline and shared somatic mutations in the gene for CCAAT-enhancer-binding protein alpha with 13 years difference at onset.
This case report demonstrates the utility of combining touch preparation with the simplicity of the Idylla instrument as a simple means to rapidly detect somatic mutations. To our knowledge, this is the first US-based report describing RAS/ BRAF testing on the Idylla system, as well as the first description of using touch preparation with this system.
Few somatic mutations were identified (an average of 7 mutations per sample) while several copy number alterations were detected, with losses of chr1, chr3, and chr17 being the most recurrent.
Vassart, "Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: Identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades," Molecular Endocrinology, vol.
van Zelst-Stams et al., "Somatic mutations in MLH1 and MSH2 are a frequent cause of mismatch-repair deficiency in lynch syndrome-like tumors," Gastroenterology, vol.
Wurgler, "The somatic white-ivory eye spot test does not detect the same spectrum of genotoxic events as the wing somatic mutation and recombination test in Drosophila melanogaster," Environmental and Molecular Mutagenesis, vol.
It provided TCGA Level 3 data, including somatic mutations, mRNA expression, and DNA methylation.
For instance, Dendrix was a pathway-based algorithm for discovery of mutated driver pathways in cancer using somatic mutation data [19].