Suit-ability of
soluble transferrin receptor for the clinical diagno-sis of different types of anaemia in children.
Increased erythropoietic activity causes TfR synthesis to be upregulated and thereby increase the
soluble transferrin receptor (sTfR) level.
Serum
soluble transferrin receptor reflects erythropoiesis but not iron availability in erythropoietin-treated chronic hemodialysis patients.
Conclusion: The ratio of
soluble transferrin receptor to ferritin was lower in higher stages of chronic kidney disease.
Measurement of
soluble transferrin receptor in serum of healthy adults.
(7) Nonstandard abbreviations: Hb, hemoglobin; IV, intravenous; CKD, chronic kidney disease; EPO, erythropoietin; GI, gastrointestinal; sTfR,
soluble transferrin receptor; TDI, total dose administered in a single infusion; AERS, Adverse Event Reporting System.
[4] Nonstandard abbreviations: TIR,
soluble transferrin receptor; HH, hereditary hemochromatosis; IDA, iron-deficiency anemia; AI, anemia of inflammation; TS, transferrin saturation; NTBI, non-transferrin-bound iron; HJV, hemojuvelin; GPI, glycosylphosphatidylinositol; OMIM, Online Mendelian Inheritance in Man; HHCS, hereditary hyperferritinemia congenital cataract syndrome; DcytB, duodenal cytochrome B; DMT1, divalent metal transporter 1; HCP1, heme carrier protein 1; sTIR, soluble transfer receptor; and R/F, ratio of sTIR to the log of the ferritin concentration.
When a CHr <28 pg was used for identification of ID and FID in anemic patients, the values of ferritin,
soluble transferrin receptor (sTfR), and the sTfR-F index (sTfR/ log ferritin) (4) performed significantly better in patients without APR [based on a C-reactive protein (CRP) cutoff of 5 mg/L].
The introduction of new laboratory tests, especially
soluble transferrin receptor (sTfR), has enabled the identification of storage iron depletion, iron-deficient erythropoiesis, iron deficiency anemia (IDA), and functional ID as readily distinguishable clinical conditions (1-5).
The
soluble transferrin receptor (sTfR) has been introduced as a promising new diagnostic tool for differentiating between iron deficiency anemia (IDA) and anemia of chronic disease (ACD) (1-3).
Because the
soluble transferrin receptor (sTfR) concentration is not influenced by acute-phase reactions, it remains within reference values in patients with anemia of chronic disease.
Serum
soluble transferrin receptor (sTfR) has been established in recent years as a powerful tool for detecting iron deficiency (ID) in adults, especially in distinguishing between iron deficiency anemia (IDA) and anemia of chronic disease (1-8).
