crassiceps soluble antigen
increases IL-4 in serum.
In a previous paper we have evaluated the regulation and proliferation induced by soluble antigens
of epimastigotes or trypomastigotes (24).
The use of soluble antigen
(SA) in serum of patients with Chagas' disease showed higher cross-reactivity (6/10).
However, we also demonstrate that although the complex is internalized and presented, there is no improvement in antigen presentation when compared to soluble antigen
and thus it does not enhance indirect allopresentation.
Systemic administration of soluble antigens
is a well-accepted approach to induce immunological tolerance .
The soluble antigens
, mainly represented by toxins, are deeply involved in the pathogenesis of blackleg.
This procedure was repeated three times to completely wash all soluble antigens
from the remaining parasite membranous fraction.
There is a 100-fold enhanced presentation of soluble antigens
to T cells after being internalized by the MR on DCs, as compared to antigens internalized via fluid phase .
They also showed for the first time that CD141hi DCs were superior at cross-presenting soluble antigens
compared to other DCs to activate the killer T cells.
Some suppression of cell-mediated immunity occurs, and maternal lymphocytes demonstrate a diminished proliferative response to soluble antigens
and to allergenic lymphocytes.
The infusion sedimentation theory describes the infusion of water soluble antigens
from saliva into the tooth such as dentine.
Unlike a type II response, type III hypersensitivity is associated with responses to soluble antigens
that are not combined with host tissues but with antibodies in the blood, which can then lead to inflammatory responses.