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Related to solifenacin: Solifenacin succinate
Pregnancy Category: C
ClassificationTherapeutic: urinary tract antispasmodics
Overactive bladder with symptoms (urge incontinence, urgency, frequency).
Acts as a muscarinic (cholinergic) receptor antagonist; antagonizes bladder smooth muscle contraction.
Decreased symptoms of overactive bladder.
Absorption: Well absorbed (90%).
Protein Binding: 98%.
Metabolism and Excretion: Extensively metabolized by the CYP3A4 enzyme system. 69% excreted in urine as metabolites, 22% in feces.
Half-life: 45–68 hr.
|Oral||unknown||3–8 hr||24 hr|
Contraindicated in: Hypersensitivity;Urinary retention;Gastric retention;Uncontrolled angle-closure glaucoma;Severe hepatic impairment; Lactation: Lactation.
Use Cautiously in: Concurrent use of CYP3A4 inhibitors (use lower dose/clinical monitoring may be necessary);Moderate hepatic impairment (lower dose recommended);Renal impairment (dose should not exceed 5 mg/day if CCr <30 mL/min);Bladder outflow obstruction;GI obstructive disorders, severe constipation, or ulcerative colitis;Myasthenia gravis;Angle-closure glaucoma; Obstetric: Use only if maternal benefit outweighs fetal risk; Pediatric: Safety not established.
Adverse Reactions/Side Effects
Central nervous system
Ear, Eye, Nose, Throat
- blurred vision
- constipation (most frequent)
- dry mouth (most frequent)
- muscle weakness
- angioedema (life-threatening)
Drug-Drug interactionDrugs that induce or inhibit the CYP3A4 enzyme system may significantly alter levels; ketoconazole ↑ levels and risk of toxicity (do not exceed 5 mg/day).
Oral (Adults) 5 mg once daily, may be ↑ to 10 mg once daily; Concurrent use of ketoconazole or other potent CYP3A4 inhibitors—Dose should not exceed 5 mg/day.
Renal Impairment(Adults) CCr <30 mL/min—Dose should not exceed 5 mg/day.
Hepatic Impairment(Adults) Moderate hepatic impairment—Dose should not exceed 5 mg/day.
Tablets: 5 mg, 10 mg Cost: All strengths $703.66 / 90
- Monitor voiding pattern and assess symptoms of overactive bladder (urinary urgency, urinary incontinence, urinary frequency) to and periodically during therapy.
Potential Nursing DiagnosesImpaired urinary elimination (Indications)
- Do not confuse Vesicare (solifenacin) with Vesanoid (oral tretinoin).
- Oral: Administer once daily without regard to food. Tablets must be swallowed whole; do not break, crush, or chew.
- Instruct patient to take solifenacin as directed. Advise patient to read the Patient Information before starting therapy and with each prescription refill. If a dose is missed, skip dose and take next day; do not take 2 doses in same day.
- Do not share solifenacin with others; may be dangerous.
- May cause dizziness and blurred vision. Caution patient to avoid driving and other activities that require alertness until response to medication is known.
- Advise patient to notify health care professional immediately if hives; rash; swelling or lips, face, tongue, or throat; trouble breathing occurs.
- Inform patient of potential anticholinergic side effects (constipation, urinary retention, blurred vision, heat prostration in a hot environment).
- Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
- Decrease in symptoms of overactive bladder (urge urinary incontinence, urgency, frequency).
indication This drug is used to treat overactive bladder.
contraindications Uncontrolled narrow-angle glaucoma, urinary retention, gastric retention, and known hypersensitivity to this drug prohibit its use.
adverse effects Adverse effects of this drug include anxiety, paresthesia, fatigue, headache, chest pain, hypertension, abdominal pain, dry mouth, dyspepsia, dysuria, urinary retention and frequency, urinary tract infection, rash, pruritus, bronchitis, cough, pharyngitis, and upper respiratory tract infection. Common side effects include dizziness, vision abnormalities, xerophthalmia, nausea, vomiting, anorexia, and constipation.