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The sodium-iodine symporter, which pumps iodine into the cells against a gradient will achieve a maximal response when serum iodine levels approach [10.
Since thyroid cancer cells have a lower expression of sodium-iodine symporters, and therefore have a decreased ability to concentrate iodine compared with normal thyroid tissue,4 better diagnostic accuracy is obtained from the radioiodine scan when the patient is administered thyroid-stimulating hormone (TSH).
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