Sodium cyclamate can also cross blood placental barrier suggesting retardation in development of placenta and restriction in intrauterine fetal growth6.
Not much work has been done upon the effects of sodium cyclamate on pancreas.
In the light of previous studies the rationale of current study was to access the effects of sodium cyclamate on histomorpholgy of endocrine pancreas and to observe any change in the area of islets of langerhans.
In the present study the placentas of 10 rats were evaluated, divided into 5 treated rats and 5 control rats, chosen at random; the treated rats received 60 mg/Kg of body weight sodium cyclamate intraperitoneally from the 10th to 14th day of gestation, and the 5 rats from the control group received by the same route, the equivalent volume of saline solution 0.9%.
The quantitative parameters of fetal weight, placental weight and umbilical-cord length, for both controls and the group treated with sodium cyclamate, as well as its statistical analysis, can be seen in Table I.
The cariometric parameters of the placenta decidua in rats from the control group and those treated with sodium cyclamate, as well as their statistical analysis, can be seen in Table II, where it can be observed that cariometric parameters presented no statistically significant difference between animals of the control and treated groups.
(1994) that in Brazilian diabetics the consumption of this additive is less than 50 mg / Kg of body weight in relation to acceptable daily ingestion (Gottinger et al., 1968; Assuncao et al.), the group which is expected to present elevated utilization of edulcorants, it is known that the saccharine substitution is growing, and can affect pregnant women, which represents a great risk, because according to Pitkin et al., sodium cyclamate can cross the placental barrier and approach a fetal concentration one fourth that of maternal one.
The present work describes fetal hepatic karyometric and stereological alterations detected in rats submitted to intraperitoneal administration of sodium cyclamate, during the gestational period.
In this study, the livers of ten rats were evaluated, five treated and five controls chosen at random, in which five rats that received from the 10th to 14th pregnancy day an intraperitoneal injection of sodium cyclamate at 60 mg/ kg of body weight (treated group) and five that received the same via saline solution 0.9% (control group).
Despite this, the World Health Organization approved the use of sodium cyclamate in 1977 asa sweetener for foods and beverages in more than 40 countries (Ahmed & Thomas, 1992).
Various studies have been completed on laboratory animals seeking to verify the toxicity of sodium cyclamate. Kroes et al.
Therefore, a research into the effects of sodium cyclamate on kidneys of rat fetuses becomes relevant, since information does not exist in the literature on morphometry of the proximal or distal convoluted tubule nor on the collecting duct in the period of greatest teratogenicity.