Sodium cyclamate is used as an artificial sweetener in many foods, beverages as well as medicines due to its odorless nature and solubility in water, propylene glycol and alcohol.
Sodium cyclamate can also cross blood placental barrier suggesting retardation in development of placenta and restriction in intrauterine fetal growth6.
Not much work has been done upon the effects of sodium cyclamate on pancreas.
The objective of the present study will be to evaluate placental morphometric alterations detected in rats submitted to intraperitoneal administration of sodium cyclamate from the tenth to fourteenth day of pregnancy, in the following manner:
In the present study the placentas of 10 rats were evaluated, divided into 5 treated rats and 5 control rats, chosen at random; the treated rats received 60 mg/Kg of body weight sodium cyclamate intraperitoneally from the 10th to 14th day of gestation, and the 5 rats from the control group received by the same route, the equivalent volume of saline solution 0.
The quantitative parameters of fetal weight, placental weight and umbilical-cord length, for both controls and the group treated with sodium cyclamate, as well as its statistical analysis, can be seen in Table I.
The present work describes fetal hepatic karyometric and stereological alterations detected in rats submitted to intraperitoneal administration of sodium cyclamate, during the gestational period.
In this study, the livers of ten rats were evaluated, five treated and five controls chosen at random, in which five rats that received from the 10th to 14th pregnancy day an intraperitoneal injection of sodium cyclamate at 60 mg/ kg of body weight (treated group) and five that received the same via saline solution 0.
The quantitative parameters for fetal weight, placenta weight and umbilical-cord length in both control rat fetuses (C) and those treated with sodium cyclamate (T) can be see in Table I as well as the statistical analysis.
2002), evaluating the toxicity of sodium cyclamate in kidneys of rats, found that 3 and 24 hours after a single 2.
Therefore, a research into the effects of sodium cyclamate on kidneys of rat fetuses becomes relevant, since information does not exist in the literature on morphometry of the proximal or distal convoluted tubule nor on the collecting duct in the period of greatest teratogenicity.
The objective of this study was to evaluate the effects of sodium cyclamate on the kidneys of rat fetuses, in terms of morphometric alterations in the glomerulus, proximal and distal convoluted tubules and collecting duct.