Metformin, for example, comes from plant French lilac, artemether from qinghaosu, sodium cromoglycate
Most known and prescribed mast cell stabilizing drugs including ketotifen and sodium cromoglycate
inhibit histamine and prostaglandin release from the sensitized mast cells by preventing their degranulation.
Systemic therapies include corticosteroids, azathioprine, cyclosporine, sodium cromoglycate
, mycophenolate mofetil, ketoconazole, methotrexate and phototherapies.5 Numerous types of phototherapies have undergone trials for the treatment of severe atopic dermatitis and proven to be effective.
, nedocromil sodium, pemirolast, and lodoxamide; (3) Dual acting agents - they have both antihistaminic and mast cell stabilizing properties, e.g., olopatadine, ketotifen, azelastine, and epinastine; (4) Non-steroidal anti-inflammatory drugs, e.g., ketorolac, diclofenac, and flurbiprofen; (5) Corticosteroids, e.g., prednisolone, hydrocortisone, fluorometholone, loteprednol, and desonide.
(1) Eleven trials that included 899 children and adults compared mast cell stabilizers (sodium cromoglycate
, nedocromil, and lodoxamide tromethamine) with placebo.
Drugs, such as sodium cromoglycate
, nedocromil sodium, pemirolast, and lodoxamide act by stabilizing mast cells.
Comparative studies with sodium cromoglycate
, a classical mast cell stabilizer, were also made.
Topical mast cell stabilisers such as sodium cromoglycate
have been shown to be effective in moderate to severe CLGPC or to aid resolution in cases resistant to conservative management.
For this reason, sodium cromoglycate
200 mg three times a day (TID) was added to her treatment with modest improvement of her symptoms.
18 October 2010 - Japanese Astellas Pharma Inc (TYO: 4503) and sanofi-aventis K.K., part of French sanofi-aventis (EPA: SAN), said today that Astellas Pharma will transfer the distribution rights for the anti-allergic drug Intal (sodium cromoglycate
) to sanofi-aventis, effective 1 January 2011.
: Sodium cromoglycate
inhibits mast cell degranulation and its primary advantages are its minimal side effects and the fact that it is well known, having been on the market for over 30 years.