blocker

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blocker

[blok´er]

something that blocks or obstructs a passage or activity; see also antagonist and blocking agent.

α-blocker alpha-adrenergic blocking agent.

β-blocker (beta-blocker) beta-adrenergic blocking agent.

calcium channel blocker calcium channel blocking agent.

potassium channel blocker potassium channel blocking agent.

sodium channel blocker sodium channel blocking agent.

block·er

(blok'er),

An instrument used to obstruct a passage.

Farlex Partner Medical Dictionary © Farlex 2012

blocker

A popular term for anything which physically (e.g., a bed blocker, see there) or pharmacologically (e.g., a beta-blocker) impedes a process or activity.

block·er

(blok'ĕr)

1. An instrument used to obstruct a passage.

2. See: blocking agent

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

References in periodicals archive ?

In conclusion, the literature on the use of sodium bicarbonate in the management of sodium channel blocker toxicities is limited to animal research and case series; randomized trials are precluded due to ethical reasons.

There is no scientifically validated dosing of IV sodium bicarbonate (as in the management of sodium channel blocker toxicities) but it is typically dosed as 1-2 mEq/kg initially administered in bolus doses (see Table 1) and then may be administered as a continuous IV infusion after dilution in dextrose 5% solution [56].

The Role of Sodium Bicarbonate in the Management of Some Toxic Ingestions

The term Brugada phenocopies does not cover abnormal electrocardiogram patterns that are induced by sodium channel blockers (2).

Not All Brugada Electrocardiogram Patterns are Brugada Syndrome or Brugada Phenocopy

The latest guidelines, nonetheless, only require the documentation of type 1 BEP, either spontaneously or as a consequence of a provocative test with sodium channel blockers for a diagnosis of BrS [5].

Brugada Phenocopy Induced by Recreational Drug Use

Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of [Beta]-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes.

Genotype and Severity of Long QT Syndrome

A dramatic example was the rise in mortality among heart-attack survivors resulting from the use of sodium channel blockers to treat asymptomatic arrhythmias.

The use of sodium channel blockers to treat arrhythmias in cardiac patients demonstrates how marketing efforts can contradict sound medical practice.

The companies helped popularize the term "potentially malignant arrhythmias" for these asymptomatic skips in heartbeat and developed several new drugs (known as sodium channel blockers) that could correct them.

The trial was halted because it clearly showed that the three sodium channel blockers being studied (encainide, flecainide, and morizicine) increased mortality--even though they had effectively corrected the arrhythmia.

A prescription for better prescriptions

It can be unmasked by sodium channel blockers and febrile states.

Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report

Highlights will include insight into the controlling of the excitability of peripheral nerves; potential propagation in different subtypes of sensory neurons; the firing pattern of exons; and sodium channel blockers.

SMi's 16th Annual Pain Therapeutics Meeting to Feature Key Updates from UCL on Translational Biomarkers Following Recent Clinical Breakthrough