La Crosse virus (LACV), snowshoe hare virus (SSHV), Tahyna virus (TAHV), Jamestown Canyon virus (JCV), and Inkoo virus (INKV) are members of the CSG that have been reported to cause neurologic disease in humans.
Snowshoe hare virus causing meningoencephalitis in a young adult from northern Manitoba, Canada.
Snowshoe hare virus
(SSHV) or JCV and various dilutions of deer serum samples were incubated at 37[degrees]C for 1 h in tissue culture media, then added to Vero cell monolayers.
California serogroup (CSG) viruses (family Bunyaviridae, genus OrthobunyaviruS) (1) include the mosquitoborne pathogens Jamestown Canyon virus (JCV), snowshoe hare virus (SSHV), and La Crosse virus.
Serologic test results for a patient with California serogroup virus infection associated with encephalitis and cognitive decline, Canada, 2015 * Virus July 31 Augu st 10 August 21 Jamestown Canyon virus ELISA IgM Negative Equivocal Positive PRNT titer 1:40 1:1 60 1:320 Snowshoe hare virus ELISA IgM Negative Equivocal Positive PRNT titer 1:20 1:320 1:320 * PRNT, plaque reduction neutralization test.
CHATV strains have [approximately equal to] 84% aa identity with INKV within the nucleocapsid protein but are more similar to the Snowshoe hare virus
(93% nucleocapsid protein identity) that occurs in the United States.
An increase in titer between the acute- and convalescent-phase samples was found only for California encephalitis and snowshoe hare virus
. The titers for the convalescent-phase serum were 1:320 for California encephalitis and 1:180 for the closely related snowshoe hare virus
(Table), which has never been reported in California.