smudge cell

smudge cell

Etymology: ME, sogen, to soil
a disrupted lymphocyte, sometimes seen during preparation of blood smears.

smudge cell

Haematology
A term of art for red-purple nuclear debris with clumped chromatin and rounded nucleolar remnants, which corresponds to degenerated lymphocytes of ALL or CLL, and nucleated red cells. 

Liver pathology
An enlarged basophilic hepatocyte, replete with adenovirus particles.
 
Lung pathology
Diffusely basophilic, streaked CMV-infected (or less commonly, adenovirus-infected) alveolar and bronchial cells with indistinct nuclear:cytoplasmic interface due to vacuolisation of nuclear membrane.

smudge cell

a ruptured leukocyte, seen in a blood smear.
References in periodicals archive ?
Peripheral blood smearshowing a leukemic promyelocyte, CLL lymphocyte, and a smudge cell (Wright-Giemsa, X 1000).
WBC Toxic granulations 28 Dohle bodies 5 Vacuolations 38 Smudge cells 32 Clefted lymphocytes 10 Hairy projections 2 Auer rods 2 RBC Anisocytosis 54 Poikilocytosis 31 Microcytosis 7 Macrocytosis 2 Hypochromasia 3 Polychromasia 35 Echinocytes (burr cells) 19 Dacrocytes (teardrops) 16 Spherocytes 6 Target cells 2 Acanthocytes 1 Ovalocytes 28 Schistocytes 5 Stomatocytes 2 Howell-Jolly bodies 1 Basophilic stipplings 5 Platelet Clumped platelets 3 Platelet satellitosis 5 Large platelets 8 Giant platelets 8 Overall Cell Morphology Code Concordance, Overall Type % Concordance, % WBC Toxic granulations 78.
Non-leucocyte classifications were also examined and the cells incorrectly identified as nucleated red cells, giant platelets, platelet aggregates, smudge cells or arte facts were reclassified.
Some of us think that if the differential is performed using the slide prepared with albumin and smudge cells are not seen, that they should not be reported.
If a manual differential is required, however, an albumin-prepared smear is often necessary due to an abundance of smudge cells on the non-albumin slide (thereby hindering an accurate counting of the lymphocytes and prolymphocytes).
The grade is determined for hyposegmentation, by the percentage of neutrophils with bilobed and unilobed nuclei; for hypogranularity, by the number of hypogranular cells as a percentage of all granulocytes; for cytoplasmic fragments and hypogranular platelets, as a percentage of the sum of all platelets and cytoplasmic fragments; and for smudge cells, based on smudge cells as a percentage of all white blood cells.
Throughout this episode the patient had WBC counts of >300,000/L with significant smudge cells showing on the differential smear.