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Related to smouldering: smouldering myeloma

adult T-cell leukemia-lymphoma

Oncology A rapidly-progressive lymphoproliferative malignancy of mature T lymphocytes, commonly associated with infection by the retrovirus, HTLV-I, first described in southeastern Japan, also seen in the Caribbean, Africa and in blacks in the southeastern US, in whom the disease is aggressive with skin lesions, hypercalcemia, rapid enlargement of hilar, retroperitoneal and peripheral lymph nodes with mediastinal sparing, invasion of CNS, lungs, GI tract, opportunistic infections–eg,.Pneumocystis carinii. See T-cell lymphoma.
Adult T-cell leukemia-lymphoma–clinical forms
Acute
Median age 52, lymphadenopathy, hepatosplenomegaly, cutaneous lesions, up to a 20-year latency, often resistant to chemotherapy with poor prognosis following disease onset Lab ↑ Ca++, WBCs 10-500 × 109–US: 10-500 000/mm3, Sezary-like cells with CD3, CD4, CD2, and Tac+ surface antigens, causing a chronic, smoldering lymphoma
Chronic
Clinically between acute and smoldering disease
Smoldering
Characterized by erythematous skin nodules filled with lymphocytes that may undergo 'blast transformation' to the typical acute T cell leukemia
Crisis
When either 2. or 3. transform to ATL
Lymphoma
Most common in US; affects blacks with hypercalcemia, leukemia, hepatosplenomegaly, erythematous skin lesions, lytic bone lesions
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

smoldering

Of some cancers or infections, developing, growing, or progressing slowly.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
<BRyton Golf club at Clara Vale and its smouldering fourth fairway
The white paper warned that "certain disputes over land territory are still smouldering".
"The fire is not free-burning now, it is just smouldering material," Mr Howard-Jones said.
Bobbi Brown Black Pearl Eyeshadow Palette, PS42 I love this smouldering new palette, because you can go as natural or as naughty as you like.
SMOULDERING HOT J Supermodel Miranda Kerr MAKING IT EASY Miranda does not appear to break sweat working out
Smouldering in Forgotten was formed in 2005 and today stands proudly as Bahrain's most explosive extreme metal act.
A blaze never fully broke out, but the sofa kept smouldering slowly through the night, and filled the house with poisonous smoke.
There is heightened concern that a smouldering Chinese lantern could easily cause such fires.
He added that it is not possible to determine whether the blaze developed through flames or smouldering because there was not enough evidence of the fuel that fed it, or the way that fuel was arranged or "configured".
Put another way, despite Pattinson's famously smouldering looks, Tyler's hardly a catch, but somehow he manages to snare Ally (Emilie de Ravin), the daughter of a cop (Chris Cooper) who recently roughed him up.
The pair found four railway sleepers smouldering and one with a 4in hole burned through it.
The report says: "This breakdown caused localised overheating leading to a slow developing smouldering fire which spread throughout the ceiling void, eventually breaking through the timber flooring of the roof storage area, allowing a supply of air into the void causing the smouldering fire to become a rapidly developing flaming fire."