smoldering


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adult T-cell leukemia-lymphoma

Oncology A rapidly-progressive lymphoproliferative malignancy of mature T lymphocytes, commonly associated with infection by the retrovirus, HTLV-I, first described in southeastern Japan, also seen in the Caribbean, Africa and in blacks in the southeastern US, in whom the disease is aggressive with skin lesions, hypercalcemia, rapid enlargement of hilar, retroperitoneal and peripheral lymph nodes with mediastinal sparing, invasion of CNS, lungs, GI tract, opportunistic infections–eg,.Pneumocystis carinii. See T-cell lymphoma.
Adult T-cell leukemia-lymphoma–clinical forms
Acute
Median age 52, lymphadenopathy, hepatosplenomegaly, cutaneous lesions, up to a 20-year latency, often resistant to chemotherapy with poor prognosis following disease onset Lab ↑ Ca++, WBCs 10-500 × 109–US: 10-500 000/mm3, Sezary-like cells with CD3, CD4, CD2, and Tac+ surface antigens, causing a chronic, smoldering lymphoma
Chronic
Clinically between acute and smoldering disease
Smoldering
Characterized by erythematous skin nodules filled with lymphocytes that may undergo 'blast transformation' to the typical acute T cell leukemia
Crisis
When either 2. or 3. transform to ATL
Lymphoma
Most common in US; affects blacks with hypercalcemia, leukemia, hepatosplenomegaly, erythematous skin lesions, lytic bone lesions

smoldering

Of some cancers or infections, developing, growing, or progressing slowly.
References in periodicals archive ?
The patient's immunodepression from smoldering myeloma and chronic HCV likely favored vaginal colonization by B.
1) CPSC-16 CFR Chapter 11, Subchapter D, Ignition of Upholstered Furniture by Small Open Flames and/or Smoldering Cigarettes: Advance Notice of Proposed Rulemaking: Request for Comments and Information, Federal Register, Vol.
In some instances, crisis situations may be either sudden or smoldering, depending on the amount of advance notice and the chain of events in the crisis.
Unfortunately, the only treatment option for patients with smoldering multiple myeloma is 'watchful waiting' until they progress to active multiple myeloma, a situation which can be frustrating to both patients and their clinicians.
The smoldering waste dump has at times inundated the town of Lockhart with smoke.
The company has called the underground problems a smoldering event while the state has called it a fire.
ALVADORE - Investigators say a fire that damaged a Lane Rural Fire/Rescue station west of Eugene on Tuesday most likely started when dry, smoldering straw ignited fuel kept in a fire engine's storage compartment.
Hayek is smart and smoldering, but Farrell seems wrong for Bandini.
Even the love poems in this collection derive their sensuality from meticulous observations of the world: "Tonight I know your body, a pine-shadow eclipse of mine / the glow of cedar smoldering in darkness.
That feature suggests a slow, smoldering fire, Edwards notes.
A political firestorm that toasts the politicians responsible for these destructive poll ties is desperately needed to save the Golden State from being reduced to smoldering ruins.
These centers will report incidents that involved the ignition, melting or smoldering of clothing worn by children.