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adult T-cell leukemia-lymphoma

Oncology A rapidly-progressive lymphoproliferative malignancy of mature T lymphocytes, commonly associated with infection by the retrovirus, HTLV-I, first described in southeastern Japan, also seen in the Caribbean, Africa and in blacks in the southeastern US, in whom the disease is aggressive with skin lesions, hypercalcemia, rapid enlargement of hilar, retroperitoneal and peripheral lymph nodes with mediastinal sparing, invasion of CNS, lungs, GI tract, opportunistic infections–eg,.Pneumocystis carinii. See T-cell lymphoma.
Adult T-cell leukemia-lymphoma–clinical forms
Acute
Median age 52, lymphadenopathy, hepatosplenomegaly, cutaneous lesions, up to a 20-year latency, often resistant to chemotherapy with poor prognosis following disease onset Lab ↑ Ca++, WBCs 10-500 × 109–US: 10-500 000/mm3, Sezary-like cells with CD3, CD4, CD2, and Tac+ surface antigens, causing a chronic, smoldering lymphoma
Chronic
Clinically between acute and smoldering disease
Smoldering
Characterized by erythematous skin nodules filled with lymphocytes that may undergo 'blast transformation' to the typical acute T cell leukemia
Crisis
When either 2. or 3. transform to ATL
Lymphoma
Most common in US; affects blacks with hypercalcemia, leukemia, hepatosplenomegaly, erythematous skin lesions, lytic bone lesions

smoldering

Of some cancers or infections, developing, growing, or progressing slowly.
References in periodicals archive ?
Dutchman Smolders won the championship with 278 points in 15 rounds started in Miami last April.
First feature by writer-academic Olivier Smolders, whose occasional shorts the past 20 years have been in a similarly Expressionist vein, is perfectly tailored for fantasy festivals and other specialist events but, despite its visual merits, won't travel far beyond Euro arthouse niches.
Landscape designer Avril Smolders said: "This is an excellent example of partnership working.
Each day the fire smolders, it becomes more likely that someone walking across the overgrown lot could fall through the upper layer and land in a pit of hot embers.
Danny Smolders brings a wealth of experience working for major European telecommunications operators over the past 12 years in different roles spanning Europe, Canada, Brazil and China.
The blurb on the jacket says it all--"She never knew what she wanted--until she came to Greenwich Village and found the love that smolders in the shadows of the twilight world.