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adult T-cell leukemia-lymphoma

Oncology A rapidly-progressive lymphoproliferative malignancy of mature T lymphocytes, commonly associated with infection by the retrovirus, HTLV-I, first described in southeastern Japan, also seen in the Caribbean, Africa and in blacks in the southeastern US, in whom the disease is aggressive with skin lesions, hypercalcemia, rapid enlargement of hilar, retroperitoneal and peripheral lymph nodes with mediastinal sparing, invasion of CNS, lungs, GI tract, opportunistic infections–eg,.Pneumocystis carinii. See T-cell lymphoma.
Adult T-cell leukemia-lymphoma–clinical forms
Acute
Median age 52, lymphadenopathy, hepatosplenomegaly, cutaneous lesions, up to a 20-year latency, often resistant to chemotherapy with poor prognosis following disease onset Lab ↑ Ca++, WBCs 10-500 × 109–US: 10-500 000/mm3, Sezary-like cells with CD3, CD4, CD2, and Tac+ surface antigens, causing a chronic, smoldering lymphoma
Chronic
Clinically between acute and smoldering disease
Smoldering
Characterized by erythematous skin nodules filled with lymphocytes that may undergo 'blast transformation' to the typical acute T cell leukemia
Crisis
When either 2. or 3. transform to ATL
Lymphoma
Most common in US; affects blacks with hypercalcemia, leukemia, hepatosplenomegaly, erythematous skin lesions, lytic bone lesions

smoldering

Of some cancers or infections, developing, growing, or progressing slowly.
References in periodicals archive ?
Smoldering combustion can be initiated by weak sources of heat and yields a high conversion of fuel to toxic products per unit mass smoldered (particularly CO and heavy molecules).
Dutchman Smolders won the championship with 278 points in 15 rounds started in Miami last April.
Landscape designer Avril Smolders said: "This is an excellent example of partnership working.
By Yash Mudgal/Doha Harrie Smolders of the Netherlands won the first 5* Class 1.55m International competition of the Longines Global Champions Tour final leg on the 13-year-old bay Ragina Z at the magnificent Al Shaqab arena here yesterday.
At Duffy Lake, where two inches of snow fell Tuesday, small hot spots smoldered between piles of snow.
Since late August, they've dumped more than 10,000 gallons of water on the vacant lot in the southeast corner of the intersection, but still the fire smolders and smokes as far as 10 feet below the surface, District Fire Chief Dan Wirth said Friday.
Beebo Brinker, recently reissued with an admirably lurid cover, is probably the best-known novel (although not the one with the best sex scenes; that would be, Journey to a Woman) of Ann Bannon, billed on the cover as "Queen of Lesbian Pulp Fiction." The blurb on the jacket says it all--"She never knew what she wanted--until she came to Greenwich Village and found the love that smolders in the shadows of the twilight world." Today, Beebo is more interesting as historical document than as fiction.
Each tendril splits into two, and each new tendril divides as the fuel smolders.