small round cell tumour

small round cell tumour (adult)

A generic term for a malignancy composed of small (< 14 µm in diameter) round cells.

Examples
Neuroblastoma, rhabdomyosarcoma, lymphoma, mesenchymal chondrosarcoma, poorly differentiated synovial sarcoma, Ewing sarcoma, small cell carcinoma of lung, Merkel cell carcinoma, melanoma. The term is by definition non-specific: ancillary studies, especially immunohistochemistry, are mandatory to identify specific tumour antigens.

Small round cell tumour panel
S-100, CK, LCA.

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References in periodicals archive ?

The microscopic diagnosis was malignant, small round cell tumour, hemithorax.

Peripheral primitive neuroectodermal tumour of the pleura in a young adult-a case report

A variety of tumours have overlapping morphological features such as EWS, rhabdomyosarcoma, lymphoma, desmoplastic small round cell tumour, etc.

Some of the lymphoblastic lymphomas and a case of desmoplastic small round cell tumour also showed FLI-1 positivity.

Immunohistochemical detection of FLI-1 protein expression in Ewing Sarcoma/peripheral primitive neuroectodermal tumour: A study of 50 cases

Ewing's Sarcoma (ES) is a small round cell tumour and accounts for one quarter of all primary bone tumours during childhood.

The differential diagnoses of small round cell tumours include neuroblastoma, primitive neuroectodermal tumours of bone (PNET), malignant lymphoma, rhabdomyosarcoma, and ES.

Primary Ewing's Sarcoma of the Spine in a Two-Year-Old Boy

Peripheral primitive neuroectodermal tumour (PNET) is a rare malignant small round cell tumour of neuroectodermal origin with variable cellular differentiation (1,2).

Fine needle aspiration cytology of unsuspected metastatic primitive neuroectodermal tumour (PNET): a case report

Diagnosis of small round cell tumour with possibility of Ewings sarcoma/PNET was given.

A case of Ewings sarcoma involving mandible, an unusual site

Specificity of the EWS/WT1 gene fusion for desmoplastic small round cell tumour.

Molecular testing of solid tumors

3) So the definitive diagnosis of most pediatric solid tumours requires extensive immunohistochemical markers because they often exhibit a nonspecific small round cell tumour phenotype.

A rare case of bilateral multifocal breast masses in a child with disseminated rhabdomyosarcoma

Here we present a cytodiagnosis of malignant small round cell tumour of palate which was confirmed on IHC as PNET.

Malignant small round cell tumour (PNET) of palate: a rare cytological diagnosis

PNETs are small round cell tumours that arise from cells of the primitive ectoderm and comprise 1% of all sarcomas.

Renal primitive neuroectodermal tumour: Case series and brief review

Difficulties in diagnosing small round cell tumours of childhood from fine needle aspiration cytology samples.