small round cell tumour

small round cell tumour (adult)

A generic term for a malignancy composed of small (< 14 µm in diameter) round cells.

Examples
Neuroblastoma, rhabdomyosarcoma, lymphoma, mesenchymal chondrosarcoma, poorly differentiated synovial sarcoma, Ewing sarcoma, small cell carcinoma of lung, Merkel cell carcinoma, melanoma. The term is by definition non-specific: ancillary studies, especially immunohistochemistry, are mandatory to identify specific tumour antigens.

Small round cell tumour panel
S-100, CK, LCA.
References in periodicals archive ?
Peripheral primitive neuroectodermal tumour (PNET) is a rare malignant small round cell tumour of neuroectodermal origin with variable cellular differentiation (1,2).
The cytologic diagnosis of PNET poses a diagnostic challenge due to overlapping cytomorphologic features with those of other small round cell tumours.
Specificity of the EWS/WT1 gene fusion for desmoplastic small round cell tumour.
PNETs are small round cell tumours that arise from cells of the primitive ectoderm and comprise 1% of all sarcomas.

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