small round cell tumour

small round cell tumour (adult)

A generic term for a malignancy composed of small (< 14 µm in diameter) round cells.

Examples
Neuroblastoma, rhabdomyosarcoma, lymphoma, mesenchymal chondrosarcoma, poorly differentiated synovial sarcoma, Ewing sarcoma, small cell carcinoma of lung, Merkel cell carcinoma, melanoma. The term is by definition non-specific: ancillary studies, especially immunohistochemistry, are mandatory to identify specific tumour antigens.

Small round cell tumour panel
S-100, CK, LCA.
References in periodicals archive ?
The microscopic diagnosis was malignant, small round cell tumour, hemithorax.
A variety of tumours have overlapping morphological features such as EWS, rhabdomyosarcoma, lymphoma, desmoplastic small round cell tumour, etc.
Some of the lymphoblastic lymphomas and a case of desmoplastic small round cell tumour also showed FLI-1 positivity.
Ewing's Sarcoma (ES) is a small round cell tumour and accounts for one quarter of all primary bone tumours during childhood.
The differential diagnoses of small round cell tumours include neuroblastoma, primitive neuroectodermal tumours of bone (PNET), malignant lymphoma, rhabdomyosarcoma, and ES.
Peripheral primitive neuroectodermal tumour (PNET) is a rare malignant small round cell tumour of neuroectodermal origin with variable cellular differentiation (1,2).
Diagnosis of small round cell tumour with possibility of Ewings sarcoma/PNET was given.
Specificity of the EWS/WT1 gene fusion for desmoplastic small round cell tumour.
3) So the definitive diagnosis of most pediatric solid tumours requires extensive immunohistochemical markers because they often exhibit a nonspecific small round cell tumour phenotype.
Here we present a cytodiagnosis of malignant small round cell tumour of palate which was confirmed on IHC as PNET.
PNETs are small round cell tumours that arise from cells of the primitive ectoderm and comprise 1% of all sarcomas.
Difficulties in diagnosing small round cell tumours of childhood from fine needle aspiration cytology samples.

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