small cell


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small cell

a short, bluntly spindle-shaped cell that contains a relatively large, hyperchromatic nucleus, frequently observed in some forms of undifferentiated bronchogenic carcinoma.
Synonym(s): oat cell

small cell

A 9–14-µm-diameter cell, with a faint or indistinct rim of cytoplasm and an oval-to-elongated nucleus with relatively dense chromatin. Small cells are “classically” poorly differentiated or undifferentiated neuroendocrine, which is confirmed by presence of cytokeratin and synaptophysin, and/or chromogranin; when a vague “crease” in the nucleus is also present, the descriptor “oat cell” was used in the past, a distinction of uncertain value. Small cells are seen in small-cell carcinomas, which are most common in lungs but also occur in bladder, breast, cervix, ovary, endometrium and nasopharynx.

DiffDx
Non-epithelial lesions with small cells include sarcomas (Ewing sarcoma, rhabdomyosarcoma of alveolar and embryonal types, granulocytic sarcoma, reticulum cell sarcoma and liposarcoma), Wilms’ tumour, neuroblastoma, lymphoma and plasmacytoma.

small cell

Oncology A 9-14 µm in diameter cell with a faint or indistinct rim of cytoplasm, and an oval-to-elongated nucleus with relatively dense chromatin; SCs are 'classically' neuroendocrine–confirmed by presence of cytokeratin and secretory granules; when a vague 'crease' in the nucleus is also present, the descriptor 'oat cell' may be used; SCs occur in small cell carcinomas (duh!), common in lungs, but also occur in bladder, breast, cervix, endometrium, nasopharynx. See Small cell carcinoma.

small cell

(smawl sel)
A short, blunt, spindle-shaped cell that contains a relatively large hyperchromatic nucleus; frequently observed in some forms of undifferentiated bronchogenic carcinoma.
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