Smurf-1

(redirected from smad ubiqiutination regulatory factor)

Smurf-1

Smad ubiqiutination regulatory factor 1. An E3 ubiquitin ligase that participates in a cascade of ubiquitin transfer reactions, targeting R-Smad1 and R-Smad5 for ubiquitination and proteosomal degradation; it appears to specifically control BMP signalling and reduce intracellular levels of R-Smads independent of BMP ligand stimulation.
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