sliding clamp

a ring-shaped protein that encircles double-stranded DNA and slides spontaneously across it, conferring high processivity on DNA polymerases.

Farlex Partner Medical Dictionary © Farlex 2012

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clamp-loader

References in periodicals archive ?

Mark Hedglin, a post-doctoral researcher in Penn State University's Department of Chemistry and a member of Benkovic's team, explained that the sliding clamp is a ring-shaped protein that acts to encircle the DNA strand, latching around it like a watch band.

The sliding clamp then serves to anchor special enzymes called polymerases to the DNA, ensuring efficient copying of the genetic material.

"The big unknown has always been how the sliding clamp and the clamp loader interact and the timing of latching and unlatching of the clamp from the DNA," said Hedglin.

Elusive step in human DNA replication process demystified

Wilson et al., "hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA," Molecular Cell, vol.

Simultaneous use of MutS and RecA for suppression of nonspecific amplification during PCR

Speaking of drive bays, all the four 5.25-inch bays have tool-less mounting mechanism which uses sliding clamps for holding drives.