sliding clamp

sliding clamp

a ring-shaped protein that encircles double-stranded DNA and slides spontaneously across it, conferring high processivity on DNA polymerases.
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3) the dna polymerase sliding clamp dnan has polymerase and dna repair activities and is an excellent drug target for the development of antibacterial agents against gram-negative and positive bacteria given the low incidence of resistance development.
Novani: Indentification and optimisation of novel anti-infective agents using multiple hit-identification strategies
Mark Hedglin, a post-doctoral researcher in Penn State University's Department of Chemistry and a member of Benkovic's team, explained that the sliding clamp is a ring-shaped protein that acts to encircle the DNA strand, latching around it like a watch band.
The sliding clamp then serves to anchor special enzymes called polymerases to the DNA, ensuring efficient copying of the genetic material.
The big unknown has always been how the sliding clamp and the clamp loader interact and the timing of latching and unlatching of the clamp from the DNA," said Hedglin.
We know that polymerases and clamp loaders can't bind the sliding clamp at the same time, so the hypothesis was that clamp loaders latched sliding clamps onto DNA, then left for some time during DNA replication, returning only to unlatch the clamps after the polymerase left so they could be recycled for further use," he added.
Part of the DNA replication process-in humans and in other life forms-involves loading of molecular structures called sliding clamps onto DNA.
Elusive step in human DNA replication process demystified
Tenders are invited for Supply of Fall body harness with fall arrestor safety belt, fall protection accessories like rope, clamp, sliding clamp, Safety net etc for Dhuvaran GBPS
Supply Of Fall Body Harness With Fall Arrestor Safety Belt, Fall Protection Accessories Like Rope, Clamp, Sliding Clamp, Safety Net
Tenders are invited for 25 Kv System Sliding Clamp For 50Mm Outer Dia Luminium Bus Bar As Per Rdso Drg No - Eti/Ohe/11190 With Latest Correction Slip.
25 kv system sliding clamp for 50mm outer dia luminium bus
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A major pathway that allows cells to overcome or bypass DNA lesions during replication is activated by posttranslational modifications of the sliding clamp protein PCNA.
Germany - Mechanistic analysis of DNA damage bypass in the context of chromatin and genome replication
25-inch bays have tool-less mounting mechanism which uses sliding clamps for holding drives.
Corsair Obsidian 550D Review

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