Other conditions that can cause excessive sleepiness
include neurological disorders such as restless legs syndrome/periodic limb movement disorder, which affects about 2% of the adult population, and conditions such as narcolepsy, affecting one in 2,000 to 3,000 people.
However, daytime sleepiness
, measured subjectively using the Epworth Sleepiness
Scale and the Karolinska Sleepiness
Scale and measured objectively using the Oxford Sleep Resistance test, did not differ significantly between the two study groups.
Moreover, the only E2006 group to show a statistically significant increase compared to placebo in next-day residual sleepiness
as measured by the Karolinska Sleepiness
Scale (KSS) was at the dose of 25 mg.
Scammell's current research focuses on mouse models of narcolepsy, as mice lacking orexins also experience sleepiness
and frequent episodes of cataplexy.
For the study, more than 600 nurses working full-time in critical care units completed a questionnaire on personal and work-related data, sleep quality, daytime sleepiness
, sleep quantity, clinical-decision self-efficacy, and decision regret.
Excessive daytime sleepiness
is a common symptom for patients with narcolepsy and obstructive sleep apnea (OSA).
University of Michigan Medical School researchers looked at school students who were bullies and found that they faced a two-fold higher risk for symptoms of sleep-disordered breathing, particularly daytime sleepiness
Of those without clinical vitamin D deficiency, higher levels of daytime sleepiness
were significantly correlated with a lower vitamin D concentration.
All study participants completed a series of question-and-answer tests to assess (1) insomnia, (2) daytime sleepiness
, (3) depression, and (4) activities of daily living.
The 'epidemic' of sleepiness
parallels an 'epidemic' of obesity and psychosocial stress," said Alexandros Vgontzas, MD, the principal investigator for the three studies.
Both are approved by the Food and Drug Administration for the management of persistent sleepiness
and fatigue in patients with sleep apnea who are compliant with their CPAP therapy, Dr.
The official said that the main reasons behind losing control over vehicles and going off road during late night is drivers' sleepiness
, as some drivers get fatigued because of driving continuously a long time without taking rest.