Eight posters including the integrated analysis of lemborexant's effects on daily function and disease severity as well as sleep onset and sleep maintenance
for the combined 1,955 patient population of two pivotal clinical Phase III studies, SUNRISE 1 (Study 304) and SUNRISE 2 (Study 303) in insomnia disorders, and an evaluation of results on respiratory function after administration of lemborexant in elderly and mild obstructive sleep apnea, and the latest pre-clinical data on ISWRD will be presented.
In the study published in the journal Scientific Reports, researchers found that every extra hour of moderate-to-vigorous physical activity made the teens fell asleep 18 minutes earlier, slept 10 minutes longer and had about one per cent greater sleep maintenance
efficiency that night.
Belsomra C-IV 5 mg, 10 mg, 15 mg and 20 mg tablets are currently approved in the United States for treatment of insomnia characterized by difficulties with sleep onset and sleep maintenance
Six-month data show significant improvements in patient-reported measures of sleep onset and sleep maintenance
for investigational agent lemborexant
Lemborexant 5mg and 10mg also provided statistically significant improvement in sleep maintenance
variables of subjective sleep efficiency and subjective wake after sleep onset compared to placebo, which were the study's key secondary endpoints.
This is called Sleep Maintenance
Insomnia -- a medial term to describe people who cannot maintain sleep.
It is the most common sleep disorder in PD cases, and these patients usually report difficulties with sleep onset and sleep maintenance
. Sleep fragmentation is a key indicator of sleep maintenance
It is primarily used to treat sleep onset insomnia which is difficulty initially falling asleep and sleep maintenance
insomnia which is waking up frequently during the night.
It was developed on the basis of seven diagnostic criteria (Morin & Espie, 2003), comprising (1) the severity of sleep onset (initial), (2) sleep maintenance
(middle), (3) early morning awakening (terminal), (4) satisfaction with current sleep pattern (satisfaction), (5) interference with daily functioning (interference), (6) noticeability of impairment attributed to the sleep problem (noticeability), and (7) level of distress caused by the sleep problem (distress).
Disorders in circadian rhythms may result in sleep onset or sleep maintenance
and excessive sleepiness .
Silverman et al., "Sleepiness, quality of life, and sleep maintenance
in REM versus non-REM sleep-disordered breathing," American Journal of Respiratory and Critical Care Medicine, vol.