The potential prognostic impact of the number of involved lymph node stations and the presence/absence of skip metastases
should also be taken into consideration as the N descriptor of 8th edition is based on anatomical location rather than the number of invaded nodes.
Ryu et al., "Sentinel node mapping and skip metastases
in patients with early gastric cancer," Annals of Surgical Oncology, vol.
However, lymph node metastases in GC do not always follow a linear pattern of lymphatic drainage, and interlocking lymphatic vessels can be responsible for the occurrence of skip metastases (14).
The technique was highly sensitive in identifying node metastases, although false negative results and skip metastases restrict the application of SN biopsy as a single method for lymphatic staging.
Frequency and therapeutic implications of 'skip metastases
' in the neck from squamous carcinoma of the oral tongue.
--pT3: Discontinuous tumors in the primary bone site (not including skip metastases)
--pM1b: Metastasis involving distant sites other than lung (including skip metastases)
Three patients (9%) had positive non-SLNs with negative SLNs, representing skip metastases
. One patient had a T2 tumor with 1 of 28 non-SLNs positive and 2 SLNs negative.