skin autofluorescence

skin autofluorescence

The abnormal fluorescence of the skin of patients with either diabetes mellitus or excessive oxidative stress when exposed to ultraviolet light. It results from the accumulation of advanced glycosylation end products (AGE) in tissues. AGE accumulation has been linked to cardiovascular diseases, impairments in glucose tolerance, and renal failure.
References in periodicals archive ?
Skin autofluorescence, relatively simple and time saving procedure, is related to the accumulation of AGE products and is one of the strongest markers to predict cardiovascular events in diabetes, renal insufficiency, and atherosclerosis itself [5].
To assess the influence of age and tested measurements on the outcome variable skin autofluorescence, the stepwise multiple regression analysis was performed.
Skin autofluorescence (SAF) measure is a promising noninvasive method to evaluate AGE deposition which correlated with AGE levels determined by biochemical analysis of skin biopsies [38].
Advanced glycation end-products and skin autofluorescence in end-stage renal disease: a review," Clinical Chemistry and Laboratory Medicine, vol.
The comparison of skin autofluorescence intensity image and image of autofluorescence photobleaching rates, both extracted from the skin video at UV-illumination, is illustrated at Fig.
Reconstruction of in vivo skin autofluorescence spectrum from microscopic properties by Monte Carlo simulation.
COPENHAGEN -- Skin autofluorescence is a strong and independent predictor of mortality in patients with well-controlled type 2 diabetes, according to data presented at the annual meeting of the European Association for the Study of Diabetes.
Andries Smit, head of the vascular unit of the University Medical Center in Groningen, the Netherlands, and medical director and founder of DiagnOptics, which markets a skin autofluorescence (AF) measuring device called the AGE Reader.
Yellow color represents skin autofluorescence excited by 405 nm; Purple color represents zinc oxide nanoparticle distribution in skin (stratum corneum) excited by 770 nm, with collagen-induced faint SHG signals in the dermal layer.
Using the same properties, a noninvasive method has been developed for assessing accumulation of AGEs in dermal proteins by measuring skin autofluorescence with a dedicated device.
Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus.