site-specific mutation

site-spe·cif·ic mu·ta·tion

an alteration of the structure of a gene at a specific sequence, usually referring to experimentally produced changes in gene sequence.
References in periodicals archive ?
Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.
The fourth variant incorporates all of the above changes and two additional site-specific mutations, T22C and S87C that form a stabilizing disulfide bridge.
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