site-specific delivery


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site-specific delivery

Any of the techniques to help a therapeutic agent concentrate in the organ where it will have the greatest effect. These include attaching a drug to a monoclonal antibody or administering prodrugs that are converted to active agents only in targeted cells.
See also: delivery

site-specific delivery

Techniques used to help a therapeutic agent concentrate in the organ where it will have the greatest effect. These include attaching a drug to a monoclonal antibody or administering prodrugs that are converted to active agents only in targeted cells.
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References in periodicals archive ?
This is widely used in a number of commercial products, including Asacol[R], Ipocol[R], Mesren[R]MR, tablets for site-specific delivery of the anti-inflammatory drug mesalazine (mesalamine) to the large intestine for the treatment of ulcerative colitis.
Opsona has developed OPN-501, an oral pro-drug for the treatment of inflammatory bowel disease (IBD) including Ulcerative Colitis and Chrohn's disease that allows site-specific delivery of the active drug to the colon while suppressing absorption in the stomach and small intestine, improving the effectiveness and reducing side effects.
The site-specific delivery targets the medication's site of action in the spinal cord, thereby minimizing the dose requirements and side effects compared to oral administration of the same drugs.

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