sirtuins


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Related to sirtuins: resveratrol

sirtuins

Enzymes that appear to be important in the biochemical processes that relate calorie intake restriction to vitality and longevity. See also RESVERATROL.
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Guarente's lab has long studied the link between aging and sirtuins, a class of proteins found in nearly all animals.
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
Enzymes within the sirtuin family can remove a negatively-charged acetyl group from the histones, thus making them more positively charged.
For example, sirtuins protect DNA from damage that can lead to potentially harmful mutations.
These increase the function of the enzyme sirtuin 6 (SIRT6) in cancer cells, regulation of this enzyme could open up new avenues for cancer treatment, revealed the researchers from the University of Eastern Finland
SIRT4, unlike other sirtuins, mostly functions as a histone ADP-ribosyltransferase but does not have NAD-dependent deacetylase activity [52].
McCall, "Sirtuins link inflammation and metabolism," Journal of Immunology Research, vol.
Class III histone deacetylase (HDAC) is also known as sirtuins (SIRTs), and the mammalian SIRT family has seven members (SIRT1-SIRT7).
SIRT3, a member of the silent information regulator (Sirtuins) family, participates in cell biological functions such as energy metabolism and cell aging by regulating mitochondrial function, and it is closely related to tumor development and progression [4-6].
Later research described the deacetylation of histone and nonhistone proteins, orchestrated by a subgroup of deacetylases known as sirtuins [14].
Sirtuins, also known as Sir2-like proteins, are a family of [NAD.sup.+]-dependent deacetylases and ADP-ribosyltransferases [6], playing a vital role in aging [7].