SIRT6

(redirected from sirtuin type 6)

SIRT6

A gene on chromosome 19p13.3 that encodes an NAD-dependent protein deacetylase that acts on Lys-9 of histone H3 at NF-kappaB target promoters, downregulating a subset of NF-kappaB target genes. Its deacetylation of nucleosomes interferes with RELA binding to target DNA. It may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance and genomic stability. It is required for normal IGF1 serum levels and glucose homeostasis. SIRT 6 modulates cell senescence and apoptosis and regulates TNF production.