SIRT4

(redirected from sirtuin 4)

SIRT4

A gene on chromosome 12q24.31 that encodes an NAD-dependent protein ADP-ribosyl transferase that catalyses the transfer of ADP-ribosyl groups onto target proteins (e.g., mitochondrial GLUD1), inhibiting its enzyme activity. SIRT4 interacts with GLUD1, IDE and SLC25A5, is widely expressed, especially in vascular smooth muscle, striated muscle and in beta-cells in pancreas islets; it downregulates insulin secretion.
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References in periodicals archive ?
Voelter-Mahlknecht, "Fluorescence in situ hybridization and chromosomal organization of the sirtuin 4 gene (Sirt4) in the mouse," Biochemical and Biophysical Research Communications, vol.
Liu, "Mitochondrial Sirtuin 4 resolves immune tolerance in monocytes by rebalancing glycolysis and glucose oxidation homeostasis," Frontiers in Immunology, vol.
Despite conserved deacetylase domains, mitochondrial sirtuin 4 (Sirt4) is the most efficient lipoamidase among mitochondrial sirtuins.
ALT: Alanine aminotransferase AST: Aspartate aminotransferase BMI: Body mass index DBP: Diastolic blood pressure HDL: High-density lipoprotein HoMA-IR: Homeostatic model assessment-insulin resistance HS: Hepatic steatosis INQ: Index of nutritional quality LDL: Low-density lipoprotein MAI: Mediterranean adequacy index MD: Mediterranean diet MUFA: Monounsaturated fatty acids PREDIMED: PREvencion con DIeta MEDiterranea PUFA: Polyunsaturated fatty acids RI: Recommended intake ROS: Reactive oxygen species SBP: Systolic blood pressure SFA: Saturated fatty acids Sirt4: Sirtuin 4 TG: Triglycerides VAI: Visceral adiposity index WC: Waist circumference [gamma]GT: Gamma glutamyl transferase.
Scopacasa et al., "Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes," Oxidative Medicine and Cellular Longevity, vol.
Colao et al., "Preliminary data on the relationship between circulating levels of Sirtuin 4, anthropometric and metabolic parameters in obese subjects according to growth hormone/insulin-like growth factor-1 status," Growth Hormone & IGF Research, vol.
Sirt4: sirtuin 4; PREDIMED: PREvencion con DIeta MEDiterranea.
Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.
Oberstein et al., "Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity," Cell, vol.