SIRT3

(redirected from sirtuin 3)

SIRT3

A gene on chromosome 11p15.5 that encodes a widely expressed NAD-dependent enzyme that deacetylates key lysine residues, activating mitochondrial target proteins (e.g., ACSS1, IDH2 and GDH), thereby playing a role in cellular energy metabolism by regulating tissue-specific ATP levels.
References in periodicals archive ?
Keywords: Rheumatoid arthritis, sirtuin 2, sirtuin 3
Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients.
trans-(-)-e-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.