SIRT2

(redirected from sirtuin 2)

SIRT2

A gene on chromosome 19q13 that encodes a widely expressed NAD-dependent enzyme that deacetylates Lys-40 of alpha-tubulin and is involved in controlling mitotic exit in the cell cycle, possibly by cytoskeletal regulation.
References in periodicals archive ?
Keywords: Rheumatoid arthritis, sirtuin 2, sirtuin 3
The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.
Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein.