single-strand break


Also found in: Acronyms.

sin·gle-·strand break

a break in double-stranded DNA in which only one of the two strands has been cleaved; both strands have not separated from each other.
References in periodicals archive ?
1 and 2 mT for 1 hr) on DNA single-strand breaks in Chinese hamster cells.
To compare with the effect of ionizing radiation, we have exposed rats to 2 Gy of X rays and assayed DNA single-strand breaks in their brain cells.
In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction.
amarus extract at a dose equivalent to 2 g/kg body weight of dried plant did not cause DNA single-strand breaks in hamster liver as detected by the alkaline-elution method (Table 2).
We used the alkaline-elution method to detect DNA single-strand breaks in hamster liver beause it is an in v ivo short-term assay that is sensitive and simple (Sripanidkulchai et al.
Detection of DNA single-strand breaks in hamster liver treated with carcinogens.
Thus, it is necessary to discuss how the observed defect in the removal of ENU-induced single-strand breaks might relate to the pathogenesis of AD.
A decreased activity of one or both of these DNA glycosylases in quiescent PBL might thus explain the slower removal of ENU-induced single-strand breaks as observed in quiescent PBL from some normal individuals |28, 31~ and familial AD patients (Table II |29~).
Induction and disappearance of DNA single-strand breaks in human B and T lymphocytes after exposure to ethyl-nitrosourea.
Oxidative damage of DNA is known to induce single-strand breaks and inter-/intrastrand cross-links (Caraceni et al.
Potent protective effect of melatonin on chromium(VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes.

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