single-chain antibody

single-chain antibody

A synthetic antibody based on a single-chain fragment, which is a fusion protein of the variable regions of the heavy and light chains of immunoglobulins, connected with a short linker peptide of 10–25 amino acids. Single chains are one of the smallest possible formats for recombinant antibodies, and have potential roles as diagnostic tools and therapeutic agents.
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COPENHAGEN -- An ultrasmall yet highly potent single-chain antibody fragment directed against tumor necrosis factor-alpha showed promise for the treatment of Behcet's disease flares in a pilot phase II study.
ESBA105 is a single-chain antibody fragment directed against TNF?
During the last decade combinatorial technologies have enabled the selection of a variety of monoclonal single-chain antibody fragments (scFv) against all types of antigens and epitopes (8-10).
This mechanism of action has been validated by experiments with single-chain antibody fragments containing the antibody binding site (15).
6) used genetic engineering to produce a single-chain antibody fragment (scFv); when this fragment was used in an assay, the assay was much less affected by nonspecific interference than was an assay of comparable design that used the parent antibody.
Enzon's science-focused strategy includes an extensive drug development program that leverages the company's macromolecular engineering technology platforms, including PEG modification and single-chain antibody (SCA) technologies.
The single-chain antibody is produced as a fusion protein containing a 17-amino acid C-terminal biotin acceptor domain that is specifically biotinylated during expression in E.
However, because of the unique polymeric differences among the protein types (dieters vs linear polymers vs cyclic polymers), we proposed that it would be feasible to develop a single-chain antibody that could be used in an ELISA to reliably differentiate among haptoglobin phenotypes.
A phage display library of single-chain antibody fragments (scFv) was constructed (12).
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