According to the company, Brolucizumab (RTH258) is a humanized single-chain antibody
fragment (scFv) to reach this stage of development.
Song et al., "SPECT and fluorescence imaging of vulnerable atherosclerotic plaque with a vascular cell adhesion molecule 1 single-chain antibody
fragment," Atherosclerosis, vol.
Dubel, "A helper phage to improve single-chain antibody
presentation in phage display," Nature Biotechnology, vol.
COPENHAGEN -- An ultrasmall yet highly potent single-chain antibody
fragment directed against tumor necrosis factor-alpha showed promise for the treatment of Behcet's disease flares in a pilot phase II study.
Bypassing hybridoma technology: HLA-C reactive human single-chain antibody
fragments (scFv) derived from a synthetic phage display library (HuCAL) and their potential to discriminate HLA class 1 specificities.
ESBA105 is a single-chain antibody
fragment directed against TNF?.
Use of an in vivo biotinylated single-chain antibody
as capture reagent in an immunometric assay to decrease the incidence of interference from heterophilic antibodies.
This mechanism of action has been validated by experiments with single-chain antibody
fragments containing the antibody binding site (15).
and Inhale announced a broad strategic alliance that includes a collaboration to develop three products using Inhale's Inhance(TM) pulmonary delivery platform or SEDS(TM) supercritical fluids platform; an agreement making Inhale solely responsible for licensing Enzon's PEG patents, which includes over 40 US patents; an option for Enzon to license Inhale's PEGylation patents; and an agreement to explore the development of non-invasive delivery of single-chain antibody
products via the pulmonary route.
According to researcher Robert Bird of the Gaithersburg, Md.-based company, recent tests show this "single-chain antibody
" binds specifically to its antigen.
According to the company, LME 636 is based on a proprietary single-chain antibody
fragment technology specifically designed for topical delivery.
During the last decade combinatorial technologies have enabled the selection of a variety of monoclonal single-chain antibody
fragments (scFv) against all types of antigens and epitopes (8-10).