To explore the relationship between environmental exposure and genetic susceptibility in the etiology of common diseases, the Environmental Genome Project is scanning environmental response genes involved in DNA repair, cell cycle control, apoptosis, drug metabolism, and other pathways for single nucleotide polymorphisms
under which Orchid will perform validation and quality control testing on single nucleotide polymorphisms
identified through the Consortium's research.
Affymetrix collaborated with the Whitehead Institute/MIT Center for Genome Research to discover many of the single nucleotide polymorphisms
represented in the new mapping assay.
These genetic markers were identified through a genome-wide study of an initial 11,647 single nucleotide polymorphisms
(SNPs) in 7,136 genes, focusing on SNPs that could influence gene function in order to increase the likelihood of identifying disease-causing gene variants.
However, since the completion of the human genome project there has been increasing interest in the use of Single Nucleotide Polymorphisms
(SNPs), which are essentially point mutations or permanent changes in the nuclear genome.
The assays can detect multiple types of polymorphisms, including single nucleotide polymorphisms
(SNPs), insertion/deletions, and multiple nucleotide polymorphisms (MNPs), and have been limited to regulatory coding regions and splice junctions.
With this funding, Perlegen will use high density oligonucleotide array technology to discover a comprehensive genome-wide set of single nucleotide polymorphisms
(SNPs) in Yersinia species which will aid in distinguishing strains and understanding their biology.
In this study, Perlegen will assay human genetic variants (also called single nucleotide polymorphisms
or SNPs) in individuals with the trait of interest (cases) compared to individuals without the trait (controls).
This study focused on several Single Nucleotide Polymorphisms
(SNPs) in genes associated with venous thromboembolism (VTE).
Multiplexed genotyping on Tm Bioscience's Tag-It(TM) platform allows up to 50 single nucleotide polymorphisms
to be swiftly determined in one tube at a lower cost.