single nucleotide polymorphism


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polymorphism

 [pol″e-mor´fizm]
the ability to exist in several different forms.
balanced polymorphism an equilibrium mixture of homozygotes and heterozygotes maintained by natural selection against both homozygotes.
genetic polymorphism the occurrence together in the same population of two or more genetically determined phenotypes in such proportions that the rarest of them cannot be maintained merely by recurrent mutation.
single nucleotide polymorphism (SNP) a genetic polymorphism between two genomes that is based on deletion, insertion, or exchange of a single nucleotide.

single nucleotide polymorphism (SNP),

the naturally occurring substitution of a single nucleotide at a given location in the genome of an organism, the more interesting of which results in phenotypic variability, including alterations in the organism's physiologic responses to endogenous hormones and neurotransmitters or endogenous substances.

single nucleotide polymorphism (SNP)

a genetic polymorphism between two genomes that is based on deletion, insertion, or exchange of a single nucleotide.

single nucleotide polymorphism (SNP, ‘snip’)

a single BASE PAIR position in genomic DNA where different sequence alternatives exist for normal individuals in the population. Differences between individual genomes are largely due to SNPs. Over 1.4 million SNPs have been identified in the human GENOME. SNPs in coding regions of the genome are designated cSNPs; those in regulatory regions, rSNPs; and those in JUNK DNA regions, anonymous SNPs. SNPs generate variability, particularly where they occur in coding regions, thereby contributing to the biological characteristics of an individual. For example SNPs reflect differences in susceptibility to, and protection from, a range of diseases. An SNP can be detected by OLIGONUCLEOTIDE HYBRIDIZATION, using for example DNA CHIPS.
References in periodicals archive ?
The global single nucleotide polymorphism genotyping market segmentation is based on technologies (AB SNPlex, MassARRAY MALDI-TOF, SNP by Pyrosequencing, SNP GeneChips and Microarrays, Taqman Allelic Discrimination, and applications (agricultural biotechnology, breeding and animal livestock, diagnostic research, pharmaceuticals and pharmacogenomics).
The global single nucleotide polymorphism genotyping market report also provides the detailed market landscape (market drivers, restraints, opportunities), market attractiveness analysis and also tracks the major competitors operating in the market and provides analysis of the company overview, financial snapshot, key products, technologies and services offered, market share analysis and recent trends in the global market.
In addition to commercializing a wide range of products and services for genetic diversity analyses, Orchid is creating value in single nucleotide polymorphism to improve existing pharmaceuticals and develop better pharmaceuticals and targets.
Only a fraction of the variation that exists has minor allele frequencies (MAF) exceeding l%, and these are referred to as single nucleotide polymorphisms (SNPs).
To explore the relationship between environmental exposure and genetic susceptibility in the etiology of common diseases, the Environmental Genome Project is scanning environmental response genes involved in DNA repair, cell cycle control, apoptosis, drug metabolism, and other pathways for single nucleotide polymorphisms (SNPs).
The phase of single nucleotide polymorphisms to define haplotypes is important in understanding and diagnosing disease.
Affymetrix collaborated with the Whitehead Institute/MIT Center for Genome Research to discover many of the single nucleotide polymorphisms represented in the new mapping assay.
was formed between leading academic centers and pharmaceutical companies to discover genetic variations, particularly single nucleotide polymorphisms, and to make those discoveries publicly available.
They first identified the most common single nucleotide polymorphisms in the CYP3A genes.
The retrospective research study performed in samples from over 2,000 individuals in three case-control studies identified two genetic variations known as single nucleotide polymorphisms (SNPs) that are associated with increased risk for early-onset heart attack.
These genetic markers were identified through a genome-wide study of an initial 11,647 single nucleotide polymorphisms (SNPs) in 7,136 genes, focusing on SNPs that could influence gene function in order to increase the likelihood of identifying disease-causing gene variants.

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