It has been demonstrated that higher serum resistin levels in T2DM are correlated with increasing age, female gender, body mass index (BMI), insulin resistance (IR), lower high density lipoproteins (HDL), high serum triglycerides (TGs), total cholesterol (TC), greater waist-to-hip ratio (WHR), high blood pressure, fasting blood glucose (FBG) and high sensitivity-C-reactive protein (hs-CRP).3,5-7 Resistin is coded by the RETN gene.2 Single nucleotide polymorphism
(SNP) at -420 position in promoter region of RETN gene is associated with activation of increased transcription directly or by augmented binding of nuclear factors resulting in increased messenger ribonucleic acid (mRNA) expression and serum levels 5,7-9 This explains the increased susceptibility in RETN-420 GG genotype to T2DM.
Impact of single nucleotide polymorphisms
in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows.
This study has investigated five single nucleotide polymorphisms
in TNF-[alpha] gene's promoter region to evaluate their relationship with recurrent pregnancy loss disorder.
Relationship between rs1800795 single nucleotide polymorphisms
and serum interleukin-6 level in different neuroblastoma-risk groups and MYCN gene amplification status groups
The global single nucleotide polymorphism
genotyping market segmentation is based on technologies (AB SNPlex, MassARRAY MALDI-TOF, SNP by Pyrosequencing, SNP GeneChips and Microarrays, Taqman Allelic Discrimination, and applications (agricultural biotechnology, breeding and animal livestock, diagnostic research, pharmaceuticals and pharmacogenomics).
Role of single nucleotide polymorphisms
in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma in Han Chinese: a case-control study.
By measuring over 100,000 single nucleotide polymorphisms
(SNPs), the array can detect more detailed copy number changes than conventional CGH, and offers many times more markers than microsatellite analysis for LOH studies.
Microarray-based method for genotyping of functional single nucleotide polymorphisms
using dual-color fluorescence hybridization.
"It is based on the measurement of different but very small electrical currents generated when guanine is paired with its correct DNA chemical partner versus an incorrect chemical partner." The incorrect chemical is a single nucleotide polymorphism
mutation or SNP, he said.
Capable of generating SNP (single nucleotide polymorphism
) data on 10,000 samples per day, it is expected to operate at a rate of 50,000 samples per day by July of this year.
In a blinded, retrospective study, Natera leveraged its single nucleotide polymorphism
technology to measure donor-derived cell-free DNA levels in 300 plasma samples from 193 unique kidney transplant patients, including 52 patients experiencing acute rejection.
A novel single nucleotide polymorphism
of the POU1F1 gene associated with meat quality traits in rabbits.