Longitudinal studies of Sin Nombre virus
in deer mouse-dominated ecosystems of Montana.
Sin Nombre virus
in deer mice captured inside homes, southwestern Montana.
Summary of laboratory-confirmed hantavirus pulmonary syndrome cases caused by viruses other than Sin Nombre virus
, United States, 1993-2007 No.
We used ELISAs to test the samples for IgG with the specific antigen for Sin Nombre virus
and for IgM with the Laguna Negra and Andes viruses.
Genetic links of the type have been reported for PUUV infections in Finland (11) and for Sin Nombre virus
infection during the outbreak in the Four Corners area of the United States (4,12), but perfect sequence match was not observed.
Using an enzyme-linked immunoglobulin M (IgM) capture immunosorbent assay (ELISA), elevated hantavirus IgM titers were found for the Muerto Canyon virus (MCV) (proposed to be renamed Sin Nombre virus
Virus culture and identification was attempted in African green monkey Vero cell cultures by indirect immunofluorescence assay and Sin Nombre virus
(SNV) polyclonal antibodies, as described for arboviruses (22).
The viruses known to cause HPS on the North American continent are Bayou virus, Black Creek Canal virus (BCCV), Choclo virus (CHOV), New York virus, and Sin Nombre virus
In binding assays, antibody to all known hantaviruses indigenous to the Americas cross-react with the N protein of Sin Nombre virus
Hantavirus pulmonary syndrome (HPS) was first recognized in 1993 after an outbreak of acute respiratory distress syndrome associated with Sin Nombre virus
occurred in the southwestern United States (1).
In the United States, most HPS cases are likely caused by Sin Nombre virus
(6), the virus responsible for the initially identified HPS cases.