But this relief and clearing up of simple goiter is only a part of the health benefits of the new balanced ration.
Some of the pupils objected slightly to the bitter salt taste; but they didn't insist upon their opposition when it was discovered that in about three months' time the number of simple goiters among them--that is to say, of enlargement of the thyroid gland, which could readily be seen--had decreased from seventy-five to about twenty; and further trial showed that this improvement could be increased to complete cure by keeping up the remedy in the same doses for about six weeks twice each year.
The purpose of this manuscript is to review studies published during the late 1800s and early 1900s describing the effect of oral ingestion of inorganic, non-radioactive iodine/iodide in patients with simple goiter and in Graves' disease, both conditions due to iodine/iodide deficiency.
As late as 1995, the 19th edition of Remington's Science and Practice of Pharmacy, (46) continued to recommend between 0.1 to 0.3 ml daily of Lugol 5% solution in the treatment of iodine deficiency and simple goiter. The 5% Lugol solution contains 50 mg iodine and 100 mg potassium iodide per ml with a total of 125 mg elemental iodine/ml.
With the availability of thyroid extracts in the early 1900s and thyroid hormones in the 1930s, thyroidologists started using these preparations in patients with iodine deficiency and simple goiter instead of the previously used inorganic iodine/iodide preparations.
The usual approach is to give sufficient [T.sub.4] to ameliorate all symptoms of hypothyroidism and, in patients with primary hypothyroidism, to reduce serum TSH concentrations to within the normal range ..." In the battle royal for supremacy, [T.sub.4] became the uncontested winner in the treatment of simple goiter and hypothyroidism, caused by iodine deficiency and goitrogens, but the female patients became the real losers with increasing prevalence of obesity, diabetes, hypertension, and cancers of the breast and thyroid glands.
Formerly the surgical school led by Kocher opposed the use of iodine in any form of Graves' disease, holding that it increases the severity of the symptoms and may, in fact, be responsible for the development of exophthalmic from simple goiter." In the same publication, DeCourcy's own experience revealed that out of 30 cases of exophthalmic goiter in children, Lugol solution 5-10 drops (30-60 mg) three times a day "made operation unnecessary" in 11 cases.
Arem wrote regarding the evaluation of simple goiter, "To determine the cause of your goiter, your physician may order one or several of the following tests." In that list, no mention was made of urine I levels, when in fact, the most common cause of simple goiter worldwide is I deficiency.
The presence of simple goiter in a female patient is an indication of I deficiency of both the thyroid and mammary glands.
It is common knowledge that simple goiter due to I-deficiency, if left without I supplementation, will progress to nodular goiter with some of these nodules becoming cancerous.