simian virus 40


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Related to simian virus 40: adenovirus

sim·i·an vac·u·o·lat·ing vi·rus No. 40 (SV40),

a small (40-45 nm) DNA virus of the genus Polyomavirus, family Papovaviridae; the cause of seemingly inapparent infections in monkeys, especially rhesus, and a common contaminant of monkey cell cultures; the virus may cause inapparent infection in humans and may be excreted in stools of children for several weeks; it can produce fibrosarcoma in suckling hamsters, and transformation may occur in human diploid cells; it may also form "hybrid" virus in cells also infected with certain adenoviruses.
Synonym(s): simian virus 40
References in periodicals archive ?
Case-control study of simian virus 40 and non-Hodgkin lymphoma in the United States.
Human cell transformation by simian virus 40. In Vitro, 17: 1-19.
Does simian virus 40 DNA integrate into cellular DNA during productive infection?
Diethyl pyrocarbonatetreated, RNase-free water (Biotecx Labs, Houston, Tex) was used as the negative control; the positive controls were DNA extracted from brain tissue from a patient with PML (for JCV), renal tissue from a patient with histologically proven BKV nephropathy (for BKV), and from an simian virus glia cell line culture (for simian virus 40).
Characterization of human uroepithelial cells immortalized in vitro by simian virus 40. Cancer Res 47:6066-6073 (1987).
Lack of serologic evidence for prevalent simian virus 40 infection in humans.
This stain, which was also positive in the present case (not shown), is performed on paraffin-embedded tissue using an antibody against simian virus 40, which cross-reacts with other polyomaviruses.[6] So far, only in situ hybridization allows BK virus-specific detection using a probe that does not cross-react with other members of the polyomaviruses.
The coat on simian virus 40 contains a total of 360 proteins.
In every construct, the tag sequence included codes for the 11-aa KPPTPPPEPET epitope of simian virus 40 (SV40) large T-antigen (31,32).
Furthermore, alterations of tumor suppressor genes p16/CDKN2A-[P14.sup.ARF] at 9p21 and NF2 at 22q12 are often encountered in MMs.[5] Simian virus 40 may act in conjunction with asbestos, since approximately 60% of analyzed MMs show expression of simian virus 40 at the molecular level.6 Additionally, the pathogenesis of asbestos-associated injury involves the participation of a number of cell types and is characterized by an early and persistent inflammatory response that involves the generation of oxidants, growth factors, chemokines, and cytokines.[7]
Simian virus 40 in polio vaccine: follow-up of newborn recipients.