simian virus 40


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Related to simian virus 40: adenovirus

sim·i·an vac·u·o·lat·ing vi·rus No. 40 (SV40),

a small (40-45 nm) DNA virus of the genus Polyomavirus, family Papovaviridae; the cause of seemingly inapparent infections in monkeys, especially rhesus, and a common contaminant of monkey cell cultures; the virus may cause inapparent infection in humans and may be excreted in stools of children for several weeks; it can produce fibrosarcoma in suckling hamsters, and transformation may occur in human diploid cells; it may also form "hybrid" virus in cells also infected with certain adenoviruses.
Synonym(s): simian virus 40

simian virus 40 (SV40)

a vacuolating virus isolated from the kidney tissue of rhesus monkeys. SV40 produces malignancy in human and newborn hamster kidney cells and tumors when inoculated into newborn hamsters.
References in periodicals archive ?
Association of Simian Virus 40 (SV40) With Animal and Human Malignant Mesothelioma Evidence Strength of Evidence Experimental Strong Molecular Moderate but controversial Epidemiologic Moderate but controversial
Differentiation of simian virus 40 transformed human mammary epithelial stem cell lines to myo epithelial.
Does simian virus 40 DNA integrate into cellular DNA during productive infection?
SV40 Simian virus 40, which remains the general reference for all polyomaviruses.
Serum antibodies to JC virus, BK virus, simian virus 40, and the risk of incident adult astrocytic brain tumors.
Prevalence and stability of human serum antibodies to simian virus 40 VP1 virus-like particles.
The virus, tentatively named Ryukyu virus 1 (RV1), caused apparent CPE on primary kidney cells derived from a Ryukyu flying fox and on our established bat kidney T1 (BKT1) cells, which were derived from the kidney of a horseshoe bat (Rhinolophus ferrumequinum) and transformed with expression plasmid DNA encoding the large T antigen of replication origin-defective simian virus 40.
The investigation included the polyomavirus simian virus 40 (SV40), a pathogen recognized to have infected millions of humans who were vaccinated with polio vaccines produced in cultures of rhesus monkey kidney cells (2,3).
Emergent human pathogen simian virus 40 and its role in cancer.
Serological cross-reactivities between antibodies to simian virus 40, BK virus, JC virus assessed by virus-like-particle-based enzyme immunoassays.
Biological samples were collected from 39 rhesus macaques at the Swoyambhu Temple and tested by enzyme-linked immunosorbent assay, Western blot, polymerase chain reaction, or combination of these tests for evidence of infection with rhesus cytomegalovirus (RhCMV), Cercopithecine herpesvirus 1 (CHV-1), simian virus 40 (SV40), simian retrovirus (SRV), simian T-cell lymphotropic virus (STLV), simian immunodeficiency virus (SIV), and simian foamy virus (SFV).
Comparison of three rhesus groups for antibody patterns to some viruses: absence of active simian virus 40 transmission in the free-ranging rhesus of Cayo Santiago.