40-like DNA sequences in human pleural mesothelioma.
Reimann and colleagues were able to passage a simian virus
in rhesus monkeys in vivo, with a needlestick, and after two serial passages induced lymphopenia and an AIDS-like disease with wasting and susceptibility to opportunistic infections.
9 Simian Virus
40 And Mesothelioma (Natalya Baranova And Michele Carbone).
the renal and serum samples using PM1+ and PM1--as outer primers, and PM2-- (common to all PVs), JC+ (an amplified fragment of 189 bp), BK+ (an amplified fragment of 353 bp), and simian virus
40+ (an amplified fragment of 135 bp) as inner primers, all simultaneously mixed in a single reaction to distinguish the different members of the Polyomavirus genus (29) (Table 3).
Fauci said in an interview that his federal institute would finance meritorious research on the simian virus
A month later, each animal in the treatment group received a single, intra-vaginal dose of PRO 2000 (at one of three strengths) and all animals were then challenged intra-vaginally with a hybrid simian-human immunodeficiency virus (SHIV), a simian virus
that has the envelope of HIV.
Serologic studies have shown that most adults have been exposed to HPyVs, and cross-reactivity studies have shown antigenic similarities between simian virus
40 and BK polyomavirus and, to a lesser extent, between simian virus
40 and JC polyomavirus (3-5).
The latter genus consists of the BK virus, JC virus, and simian virus
offers preliminary evidence that the virus, Simian virus
40 (SV40), and asbestos fibers work together to transform healthy cells into malignant ones, resulting in mesothelioma, a rare and fatal form of cancer.
5] Simian virus
40 may act in conjunction with asbestos, since approximately 60% of analyzed MMs show expression of simian virus
40 at the molecular level.
In a study published in Tuesday's edition of the Proceedings of the National Academy of Sciences, cancer specialists claim to have determined that exposure to simian virus
40 (SV40) cooperates with exposure to asbestos fibers to cause mesothelioma.
We hypothesize that the massive increase in unsterile injecting in Africa associated with the introduction of antibiotics in the 1950's was the modern `event' that allowed several weakly pathogenic simian virus
, long native to Sub Saharan Africa, to increase in pathogenicity and complete their genetic adaptation to human hosts, emerging as the first epidemic strain of HIV by 1959.