Thus, multiple investigators have been unable to identify a simian virus
homolog of the RL1 or ORF P genes [77, 99, 100, 105, 106].
Chen et al., "Inhibition of simian virus
40 large tumor antigen expression in human fetal glial cells by an antisense oligodeoxynucleotide delivered by the JC viruslike particle," Human Gene Therapy, vol.
Kennedy, "Tumor immunity against a simian virus
40 oncoprotein requires CD8 + T lymphocytes in the effector immune phase," Journal of Virology, vol.
Enumeration of the simian virus
40 early region elements necessary for human cell transformation.
Expression of simian virus
40 early genes in transformed rat cells is correlated with maintenance of the transformed phenotype.
Reimann and colleagues were able to passage a simian virus
in rhesus monkeys in vivo, with a needlestick, and after two serial passages induced lymphopenia and an AIDS-like disease with wasting and susceptibility to opportunistic infections.
Integration of simian virus
40 deoxyribonucleic acid into the deoxyribonucleic acid of permissive monkey kidney cells.
The UROtsa cell line was derived from normal human urothelium lining the ureter and was immortalized using simian virus
40 (SV40) large T-antigen (Petzoldt et al.
40) which have shown to cause unique cancers in some people.
Researchers examined nearly 400 tumors and control tissues and found the viral footprint for simian virus
40 (SV40) in the tumors of 43 percent of patients with non-Hodgkin lymphoma.
The "footprint" of simian virus
40 (SV40) was found in 43percent of the non-Hodgkin's samples.
Lednicky, "Cell and Molecular Biology of Simian Virus
40: Implications for Human Infections and Disease," Journal of the National Cancer Institute, 91: 2(1999): 119-134.