simethicone


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simethicone

 [sĭ-meth´ĭ-kōn]
an agent used as a remedy for flatulence, and also used to prevent foaming in gastroscopy.

simethicone (simeticone (UK))

Dentinox Colic Drops (UK), Equalizer Gas Relief, GasAid, Gas-X, Gas-X Extra Strength, Genasyme, Infacol (CA) (UK), Infantaire Gas, Maximum Strength Mylanta Gas, Mylanta Gas, Mylicon, Mylicon Infant Drops, Ovol (CA), Phazyme, Wind-Eze (UK)

Pharmacologic class: Methylated linear siloxane mixture

Therapeutic class: Antiflatulent, antifoam agent

Pregnancy risk category NR

Action

Causes gas bubbles to coalesce and allows gas to pass through GI tract via belching or passing of flatus. Silicone antifoam spreads on surface of aqueous liquids, forming a film of low surface tension that causes foam bubbles to collapse.

Availability

Capsules: 95 mg, 125 mg

Capsules (liquid-filled): 125 mg, 166 mg

Drops: 40 mg/0.6 ml, 40 mg/1 ml, 95 mg/1.425 ml

Suspension: 40 mg/0.6 ml, 50 mg/5 ml

Tablets: 60 mg, 62.5 mg, 80 mg, 95 mg

Tablets (chewable): 40 mg, 80 mg, 125 mg, 150 mg, 166 mg

Indications and dosages

Excess gas in GI tract after surgery or from air swallowing, dyspepsia, peptic ulcer, or diverticulitis

Adults and children older than age 12: 40 to 125 mg P.O. q.i.d. after meals and at bedtime, up to 500 mg/day

Children ages 2 to 12: 40 mg P.O. q.i.d., up to 240 mg/day

Children younger than age 2: 20 mg P.O. q.i.d.

Contraindications

• Hypersensitivity to drug
• Intestinal perforation or obstruction

Precautions

Use cautiously in:
• abdominal pain of unknown cause (especially when accompanied by fever).

Administration

• Give as needed after meals and at bedtime.

Adverse reactions

None significant

Interactions

None significant

Patient monitoring

• Monitor GI status to assess drug efficacy.

Patient teaching

• Tell patient to take after meals and at bedtime as needed.
• Caution patient not to take dose higher than indicated on package unless prescriber approves.

si·meth·i·cone

(si-meth'i-kōn),
A mixture of dimethyl polysiloxanes and silica gel; an antiflatulent.

simethicone

/si·meth·i·cone/ (sĭ-meth´ĭ-kōn) an antifoaming and antiflatulent agent consisting of a mixture of dimethicones and silicon dioxide.

simethicone

(sĭ-mĕth′ĭ-kōn′)
n.
A mixture of methyl siloxane polymers and silica gel, used an antiflatulent drug and as an antifoaming agent in cosmetics and industrial applications.

simethicone

[simeth′ikōn]
an antiflatulent that helps the gases to dissolve in liquid by decreasing the surface tension of gas bubbles.
indication It is prescribed to disperse gas pockets in the GI tract.
contraindications There are no significant contraindications other than hypersensitivity to the medication.
adverse effects There are no significant adverse effects.

si·meth·i·cone

(si-meth'i-kōn)
A mixture of dimethyl polysiloxanes and silica gel; an antiflatulent.

simethicone

A silicone-based material with antifoaming properties used in the treatment of flatulence and often incorporated into antacid remedies.

simethicone

an antiflatulent substance consisting of a mixture of dimethyl polysiloxanes and silica gel. Called also activated dimethicone.
References in periodicals archive ?
A segment of antacids, the line primarily contains the ingredient simethicone.
Some brands add simethicone, which is supposed to reduce gas (or at least reduced the size of gas bubbles), but which has never been proven to provide relief.
Researchers have tried, among others, simethicone (which breaks up the gas bubbles-great, but the gas is still there), prokinetic agents like metoclopromide (to move things through the gut quicker), activated charcoal (to which the gas is supposed to "stick"), antibiotics (to kill off the gasproducing bacteria), and carminatives like peppermint oil (to induce belching).
One drug that scientists had high hopes for - simethicone - has an antigas effect in test tubes.
NOXAFIL Oral Suspension is a white, cherry-flavored immediate-release suspension containing 40 mg of posaconazole per mL and the following inactive ingredients: polysorbate 80, simethicone, sodium benzoate, sodium citrate dihydrate, citric acid monohydrate, glycerin, xanthan gum, liquid glucose, titanium dioxide, artificial cherry flavor, and purified water.
1 doctor-recommended antigas ingredient, simethicone, and starts working in minutes.
Neither commonly used "gas drops" containing simethicone nor acid-reducing prescriptions have been shown to work.
Wellspring marketers say Gelusil continues to offer a unique formula that combines alumina, magnesia and simethicone in a tablet.
5) However, recent studies suggest that low counts of intestinal lactobacilli may play a role in colic and have documented improved symptoms after treatment with lactobacilli compared with treatment with simethicone.
Another purported treatment, simethicone, is an organopolysiloxane that produced contradictory results in trials and probably is ineffective.