simethicone


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simethicone

 [sĭ-meth´ĭ-kōn]
an agent used as a remedy for flatulence, and also used to prevent foaming in gastroscopy.

simethicone (simeticone (UK))

Dentinox Colic Drops (UK), Equalizer Gas Relief, GasAid, Gas-X, Gas-X Extra Strength, Genasyme, Infacol (CA) (UK), Infantaire Gas, Maximum Strength Mylanta Gas, Mylanta Gas, Mylicon, Mylicon Infant Drops, Ovol (CA), Phazyme, Wind-Eze (UK)

Pharmacologic class: Methylated linear siloxane mixture

Therapeutic class: Antiflatulent, antifoam agent

Pregnancy risk category NR

Action

Causes gas bubbles to coalesce and allows gas to pass through GI tract via belching or passing of flatus. Silicone antifoam spreads on surface of aqueous liquids, forming a film of low surface tension that causes foam bubbles to collapse.

Availability

Capsules: 95 mg, 125 mg

Capsules (liquid-filled): 125 mg, 166 mg

Drops: 40 mg/0.6 ml, 40 mg/1 ml, 95 mg/1.425 ml

Suspension: 40 mg/0.6 ml, 50 mg/5 ml

Tablets: 60 mg, 62.5 mg, 80 mg, 95 mg

Tablets (chewable): 40 mg, 80 mg, 125 mg, 150 mg, 166 mg

Indications and dosages

Excess gas in GI tract after surgery or from air swallowing, dyspepsia, peptic ulcer, or diverticulitis

Adults and children older than age 12: 40 to 125 mg P.O. q.i.d. after meals and at bedtime, up to 500 mg/day

Children ages 2 to 12: 40 mg P.O. q.i.d., up to 240 mg/day

Children younger than age 2: 20 mg P.O. q.i.d.

Contraindications

• Hypersensitivity to drug

• Intestinal perforation or obstruction

Precautions

Use cautiously in:

• abdominal pain of unknown cause (especially when accompanied by fever).

Administration

• Give as needed after meals and at bedtime.

Adverse reactions

None significant

Interactions

None significant

Patient monitoring

• Monitor GI status to assess drug efficacy.

Patient teaching

• Tell patient to take after meals and at bedtime as needed.

• Caution patient not to take dose higher than indicated on package unless prescriber approves.

si·meth·i·cone

(si-meth'i-kōn),
A mixture of dimethyl polysiloxanes and silica gel; an antiflatulent.

simethicone

(sĭ-mĕth′ĭ-kōn′)
n.
A mixture of methyl siloxane polymers and silica gel, used an antiflatulent drug and as an antifoaming agent in cosmetics and industrial applications.

si·meth·i·cone

(si-meth'i-kōn)
A mixture of dimethyl polysiloxanes and silica gel; an antiflatulent.

simethicone

A silicone-based material with antifoaming properties used in the treatment of flatulence and often incorporated into antacid remedies.
References in periodicals archive ?
The adsorbed response was achieved after 10 min of evaporation and the recovery response was found to change nonlinearly with changing concentration, and it was confirmed that a higher concentration of volatile simethicone led to a longer recovery time.
Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study.
Physical parameters of antacids such as specific gravity, pH and chemical assays of Aluminum Hydroxide, Magnesium Hydroxide, Simethicone, Aluminum Phosphate, Sodium Bicarbonate, Sodium Alginate and Acid consuming Capacity were determined according to British Pharmacopeia (BP), 2007.11
The FDA has received five reports of consumers who used Maalox Total Relief, which contains bismuth subsalicylate, when they had intended to use one of the traditional Maalox antacid products, which contain aluminum hydroxide, magnesium hydroxide, and simethicone. Maalox products are manufactured by Novartis.
The FDA received five reports of consumers who used Maalox Total Relief, which contains bismuth subsalicylate, when they had intended to use one of the Maalox antacid products, which contain aluminum hydroxide, magnesium hydroxide, and simethicone. Maalox products are manufactured by Novartis.
This effect has an application for humans to, as many digestive aids feature "simethicone" to relieve excessive gassiness.
Eighty-three breast-fed infants with colic were randomly assigned to receive Lactobacillus reuteri ([10.sup.8] live organisms in oil suspension, once a day) or simethicone (30 mg twice a day) for 28 days.
Magic mouthwash or rinse: typically contains lidocaine, diphenhydramine hydrochloride, and liquid antacids such as magnesium hydroxide, aluminum hydroxide, and simethicone (Maalox[R], Novartis); effectiveness has not been demonstrated.
The coating contains polyestyline glycol, titanium dioxide, talc, simethicone stearate, emulsifiers and sorbic acid, that's what.
She pointed out that rutile is good for UV and recommended that it be coated in silica, A1203 and stearic acid, before a final coating of dimethicone and simethicone.
Phazyme is the brand name of gelcaps containing simethicone, a gas remedy for humans.
Simethicone is the ingredient in anti-gas products like Gas-X, Maalox Anti Gas and Phazyme.