simethicone


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simethicone

 [sĭ-meth´ĭ-kōn]
an agent used as a remedy for flatulence, and also used to prevent foaming in gastroscopy.

simethicone (simeticone (UK))

Dentinox Colic Drops (UK), Equalizer Gas Relief, GasAid, Gas-X, Gas-X Extra Strength, Genasyme, Infacol (CA) (UK), Infantaire Gas, Maximum Strength Mylanta Gas, Mylanta Gas, Mylicon, Mylicon Infant Drops, Ovol (CA), Phazyme, Wind-Eze (UK)

Pharmacologic class: Methylated linear siloxane mixture

Therapeutic class: Antiflatulent, antifoam agent

Pregnancy risk category NR

Action

Causes gas bubbles to coalesce and allows gas to pass through GI tract via belching or passing of flatus. Silicone antifoam spreads on surface of aqueous liquids, forming a film of low surface tension that causes foam bubbles to collapse.

Availability

Capsules: 95 mg, 125 mg

Capsules (liquid-filled): 125 mg, 166 mg

Drops: 40 mg/0.6 ml, 40 mg/1 ml, 95 mg/1.425 ml

Suspension: 40 mg/0.6 ml, 50 mg/5 ml

Tablets: 60 mg, 62.5 mg, 80 mg, 95 mg

Tablets (chewable): 40 mg, 80 mg, 125 mg, 150 mg, 166 mg

Indications and dosages

Excess gas in GI tract after surgery or from air swallowing, dyspepsia, peptic ulcer, or diverticulitis

Adults and children older than age 12: 40 to 125 mg P.O. q.i.d. after meals and at bedtime, up to 500 mg/day

Children ages 2 to 12: 40 mg P.O. q.i.d., up to 240 mg/day

Children younger than age 2: 20 mg P.O. q.i.d.

Contraindications

• Hypersensitivity to drug
• Intestinal perforation or obstruction

Precautions

Use cautiously in:
• abdominal pain of unknown cause (especially when accompanied by fever).

Administration

• Give as needed after meals and at bedtime.

Adverse reactions

None significant

Interactions

None significant

Patient monitoring

• Monitor GI status to assess drug efficacy.

Patient teaching

• Tell patient to take after meals and at bedtime as needed.
• Caution patient not to take dose higher than indicated on package unless prescriber approves.

si·meth·i·cone

(si-meth'i-kōn),
A mixture of dimethyl polysiloxanes and silica gel; an antiflatulent.

simethicone

/si·meth·i·cone/ (sĭ-meth´ĭ-kōn) an antifoaming and antiflatulent agent consisting of a mixture of dimethicones and silicon dioxide.

simethicone

(sĭ-mĕth′ĭ-kōn′)
n.
A mixture of methyl siloxane polymers and silica gel, used an antiflatulent drug and as an antifoaming agent in cosmetics and industrial applications.

simethicone

[simeth′ikōn]
an antiflatulent that helps the gases to dissolve in liquid by decreasing the surface tension of gas bubbles.
indication It is prescribed to disperse gas pockets in the GI tract.
contraindications There are no significant contraindications other than hypersensitivity to the medication.
adverse effects There are no significant adverse effects.

si·meth·i·cone

(si-meth'i-kōn)
A mixture of dimethyl polysiloxanes and silica gel; an antiflatulent.

simethicone

A silicone-based material with antifoaming properties used in the treatment of flatulence and often incorporated into antacid remedies.

simethicone

an antiflatulent substance consisting of a mixture of dimethyl polysiloxanes and silica gel. Called also activated dimethicone.
References in periodicals archive ?
Magic mouthwash Equal parts of viscous Magic mouthwash acts as lidocaine, simethicone, numbing agent and and diphenhydramine should not be Applied directly to swallowed.
Comment: Simethicone is an anti-gas agent that is widely used to treat infantile colic, although previous studies have found it to be no more effective than placebo.
Researchers have tried, among others, simethicone (which breaks up the gas bubbles-great, but the gas is still there), prokinetic agents like metoclopromide (to move things through the gut quicker), activated charcoal (to which the gas is supposed to "stick"), antibiotics (to kill off the gasproducing bacteria), and carminatives like peppermint oil (to induce belching).
One drug that scientists had high hopes for - simethicone - has an antigas effect in test tubes.
NOXAFIL Oral Suspension is a white, cherry-flavored immediate-release suspension containing 40 mg of posaconazole per mL and the following inactive ingredients: polysorbate 80, simethicone, sodium benzoate, sodium citrate dihydrate, citric acid monohydrate, glycerin, xanthan gum, liquid glucose, titanium dioxide, artificial cherry flavor, and purified water.
Mineral oil concentration of 100% gallon,antacid aluminum + magnesium hydroxide + simethicone concentration 200mg + 200mg + 20mg / 5ml suspension / jar.
IMODIUM(R) Multi-Symptom Relief combines loperamide hydrochloride (HCl) with simethicone for relief of diarrhea, as well as the gas, cramps, bloating and pressure that nearly 65% of diarrhea sufferers can also experience.
Another purported treatment, simethicone, is an organopolysiloxane that produced contradictory results in trials and probably is ineffective.
Flatulence: Two anti-flatulents available over the counter are the silicone product simethicone and activated charcoal.
They were dismissed with a diet plan as well a prescription for hydrocodone elixir and simethicone as needed for gas and bloat.
The patient developed a reaction to the dye manifested by a macular and papular skin rash with pruritus treated with diphenhydramine (Benadryl), 50 mg by mouth every eight hours and allergic diverticulitis treated with simethicone (Mylanta), 40 mg four times a day until resolution.
NuSil Technology, a leading formulator and manufacturer of silicone compounds for the healthcare industry, today announced a definitive agreement to acquire certain assets related to the ingestible Simethicone business from G.